Furuno K, Matsubara S, Ando K, Suzuki S
J Antibiot (Tokyo). 1976 Sep;29(9):950-3. doi: 10.7164/antibiotics.29.950.
Kanamycin-induced renal impairment in dehydrated rats was spared by the administration of sodium D-glucaro-1,4-lactone. In the plasma elimination and urinary excretion studies, D-glucarate-treated rats showed quick removal of the antibiotic from the body as compared with non-treated rats. Organ distribution study clearly demonstrated the potent nephrotoxicity of kanamycin and the reduction effect of D-glucarate against the nephrotoxicity. The drug level in the kidney in non-treated rats was more than two orders of magnitude higher than those in other organs such as the liver, lung and spleen, and remained high for 48 hours after antibiotic administration. In D-glucarate-treated rats the kidney content of the drug was diminished as compared with non-treated rats just after the antibiotic administration, followed by a gradual decline with time.
给予D - 葡萄糖醛酸 - 1,4 - 内酯可减轻脱水大鼠中卡那霉素诱导的肾损伤。在血浆消除和尿排泄研究中，与未治疗的大鼠相比，经D - 葡萄糖醛酸治疗的大鼠显示出抗生素从体内的快速清除。器官分布研究清楚地证明了卡那霉素的强肾毒性以及D - 葡萄糖醛酸对肾毒性的减轻作用。未治疗大鼠肾脏中的药物水平比肝脏、肺和脾脏等其他器官中的药物水平高出两个数量级以上，并且在给予抗生素后48小时内一直保持较高水平。在经D - 葡萄糖醛酸治疗的大鼠中，与刚给予抗生素后的未治疗大鼠相比，肾脏中的药物含量减少，随后随时间逐渐下降。
