Yamani A, Wood I, Sugino I, Wanner M, Zarbin M A
Department of Ophthalmology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, USA.
Am J Ophthalmol. 1999 Jan;127(1):106-8. doi: 10.1016/s0002-9394(98)00302-x.
To report the successful treatment of choroidal detachment in a patient with nanophthalmos and to report histopathologic findings in this patient's sclera.
Choroidal detachment, secondary angle closure, and nanophthalmos were diagnosed using biomicroscopy, indirect ophthalmoscopy, and echography. Full-thickness sclerectomies in four quadrants were made on the right eye. Sclerae from these sclerectomies were studied ultrastructurally.
Best-corrected visual acuity improved to RE, 20/60 from 20/100 preoperatively; the anterior chamber deepened, and the choroidal detachment resolved. Histopathologic studies of each of the three scleral layers disclosed abnormal collagen fibrils that were frayed, split, and contained lightly stained cores.
New findings include the identification of collagen with lightly stained centers and identification of differences in collagen morphology in different areas of the sclera in a nanophthalmic eye.
报告小眼球患者脉络膜脱离的成功治疗情况，并报告该患者巩膜的组织病理学发现。
使用生物显微镜检查、间接检眼镜检查和超声检查诊断脉络膜脱离、继发性房角关闭和小眼球。对右眼四个象限进行全层巩膜切除术。对这些巩膜切除术取下的巩膜进行超微结构研究。
最佳矫正视力从术前的右眼20/100提高到20/60；前房加深，脉络膜脱离消退。对三层巩膜组织病理学研究均发现胶原纤维异常，表现为纤维磨损、分裂并含有淡染的核心。
新发现包括识别出中心淡染的胶原纤维，以及在小眼球巩膜不同区域识别出胶原形态的差异。
