Vainio O, Viljanen M K, Toivanen A
Dev Comp Immunol. 1978 Jul;2(3):493-504. doi: 10.1016/s0145-305x(78)80010-x.
Germinal center formation was studied in the spleen of young chickens immunized in ovo and at the time of hatching. When immunization was performed on day 18 in ovo and on the day of hatching, the first germinal centers were observed at 4 days. This is markedly earlier than in unimmunized chickens, where the first germinal centers appear at the age of 10 days or later. Germinal center formation preceded significant antibody production. The possible role of germinal centers in the generation of immunological memory is discussed in the light of these and earlier observations.
研究了在胚胎期和孵化时免疫的幼鸡脾脏中生发中心的形成情况。当在胚胎期第18天和孵化当天进行免疫时，在第4天观察到了第一批生发中心。这明显早于未免疫的鸡，未免疫的鸡中第一批生发中心在10日龄或更晚出现。生发中心的形成先于显著的抗体产生。根据这些以及早期的观察结果，讨论了生发中心在免疫记忆产生中的可能作用。
