Aihie Sayer A, Osmond C, Briggs R, Cooper C
MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK.
Gerontology. 1999;45(2):83-6. doi: 10.1159/000022068.
Aging changes in different body system are well described, but few studies have considered the relationship between them.
The purpose of this study was, therefore, to investigate the interrelationships between markers of aging in different parts of the body.
A cross-sectional study design was used. Structural and functional markers of aging were measured in a number of different body systems.
Conditional independence analysis demonstrated that the aging markers selected clustered into two groups, either related to chronological age or adult height. Visual acuity, lens opacity, hearing threshold, cognitive decline, and the number of teeth were associated with age, while systolic blood pressure and skin thickness were related to height. Grip strength was associated with both.
The differential associations of the aging markers with chronological age and adult height suggest that different systems do not age together. This may have relevance for understanding what underlies aging, and these preliminary findings now require replication in other aging cohorts.
不同身体系统的衰老变化已有详尽描述，但很少有研究考虑它们之间的关系。
因此，本研究的目的是调查身体不同部位衰老标志物之间的相互关系。
采用横断面研究设计。在多个不同身体系统中测量衰老的结构和功能标志物。
条件独立性分析表明，所选的衰老标志物聚为两组，一组与实际年龄相关，另一组与成人身高相关。视力、晶状体混浊、听力阈值、认知衰退和牙齿数量与年龄相关，而收缩压和皮肤厚度与身高相关。握力与两者均有关联。
衰老标志物与实际年龄和成人身高的不同关联表明，不同系统并非同步衰老。这可能与理解衰老的潜在机制有关，这些初步发现现在需要在其他衰老队列中进行重复验证。
