Zhang Wei-Guang, Zhu Shu-Ying, Bai Xiao-Juan, Zhao De-Long, Jian Shi-Min, Li Juan, Li Zuo-Xiang, Fu Bo, Cai Guang-Yan, Sun Xue-Feng, Chen Xiang-Mei
Age (Dordr). 2014 Jun;36(3):9639. doi: 10.1007/s11357-014-9639-y.
The purpose of this study is to build a biological age (BA) equation combining telomere length with chronological age (CA) and associated aging biomarkers. In total, 139 healthy volunteers were recruited from a Chinese Han cohort in Beijing. A genetic index, renal function indices, cardiovascular function indices, brain function indices, and oxidative stress and inflammation indices (C-reactive protein [CRP]) were measured and analyzed. A BA equation was proposed based on selected parameters, with terminal telomere restriction fragment (TRF) and CA as the two principal components. The selected aging markers included mitral annulus peak E anterior wall (MVEA), intima-media thickness (IMT), cystatin C (CYSC), D-dimer (DD), and digital symbol test (DST). The BA equation was: BA = −2.281TRF + 26.321CYSC + 0.025DD − 104.419MVEA + 34.863IMT − 0.265DST + 0.305CA + 26.346. To conclude, telomere length and CA as double benchmarks may be a new method to build a BA.
本研究的目的是构建一个将端粒长度与实际年龄（CA）及相关衰老生物标志物相结合的生物学年龄（BA）方程。总共从北京的一个中国汉族队列中招募了139名健康志愿者。对一个遗传指标、肾功能指标、心血管功能指标、脑功能指标以及氧化应激和炎症指标（C反应蛋白[CRP]）进行了测量和分析。基于选定的参数提出了一个BA方程，以末端端粒限制片段（TRF）和CA作为两个主要成分。选定的衰老标志物包括二尖瓣环前壁E峰（MVEA）、内膜中层厚度（IMT）、胱抑素C（CYSC）、D-二聚体（DD）和数字符号试验（DST）。BA方程为：BA = −2.281TRF + 26.321CYSC + 0.025DD − 104.419MVEA + 34.863IMT − 0.265DST + 0.305CA + 26.346。总之，端粒长度和CA作为双重基准可能是构建BA的一种新方法。
