• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

补体激活替代途径的小鼠B因子。I. 纯化、特性鉴定及功能行为

Mouse factor B of the alternative pathway of complement activation. I. Purification, characterization, and functional behavior.

作者信息

Bitter-Suermann D, Burger R, Brade V, Hadding U

出版信息

J Immunol. 1976 Nov;117(5 Pt.2):1799-804.

PMID:993580
Abstract

Mouse factor B was purified and a monospecific antiserum was raised. The physicochemical data of this protein (108,000 m.w., 5.9 S, 5.9 to 6.05 isoelectric point) were determined. The functional behavior resembles that of human and guinea pig factor B and it operates efficiently in the C3 feedback cycle of the alternative pathway of complement activation. A provisional scheme is given for the operation of the C3bB enzyme on the cellular (macrophage) level.

摘要

纯化了小鼠B因子并制备了单特异性抗血清。测定了该蛋白质的物理化学数据（分子量108,000，沉降系数5.9 S，等电点5.9至6.05）。其功能行为类似于人和豚鼠的B因子，并且在补体激活替代途径的C3反馈循环中有效发挥作用。给出了C3bB酶在细胞（巨噬细胞）水平上作用的初步示意图。

相似文献

1
Mouse factor B of the alternative pathway of complement activation. I. Purification, characterization, and functional behavior.补体激活替代途径的小鼠B因子。I. 纯化、特性鉴定及功能行为
J Immunol. 1976 Nov;117(5 Pt.2):1799-804.
2
Lymphokine production by C3b-stimulated B cells.C3b刺激的B细胞产生淋巴因子。
J Immunol. 1975 Jul;115(1):139-44.
3
Interaction of zymosan and of activated properdin with factor D-depleted guinea pig serum: implications for the mechanism of initial C3 cleavage via the alternative complement pathway.酵母聚糖和活化备解素与缺乏D因子的豚鼠血清的相互作用：对通过替代补体途径初始C3裂解机制的影响。
Z Immunitatsforsch Immunobiol. 1977 Feb;152(5):402-14.
4
In vitro synthesis of factor B of the alternative pathway of complement activation by mouse peritoneal macrophages.小鼠腹腔巨噬细胞对补体激活替代途径中B因子的体外合成
Eur J Immunol. 1976 Jun;6(6):393-8. doi: 10.1002/eji.1830060604.
5
The anaphylatoxic peptide C3a of guinea pig complement. I. Purification, physicochemical and antigenetic properties.豚鼠补体过敏毒素肽C3a。I. 纯化、理化性质及抗原特性。
Z Immunitatsforsch Immunobiol. 1978 Mar;154(2):135-46.
6
Trypsin-activated complex of human factor B with cobra venom factor (CVF), cleaving C3 and C5 and generating a lytic factor for unsensitized guinea pig erythrocytes. II. Physico-chemical characterization of the activated complex.人补体B因子与眼镜蛇毒因子（CVF）的胰蛋白酶激活复合物，可裂解C3和C5并产生针对未致敏豚鼠红细胞的溶细胞因子。II. 激活复合物的理化特性
Biken J. 1975 Dec;18(4):205-14.
7
The alternative complement pathway in chickens. Purification of factor B and production of a monospecific antibody against it.鸡的替代补体途径。B因子的纯化及其单特异性抗体的制备。
Acta Pathol Microbiol Immunol Scand C. 1986 Dec;94(6):253-9.
8
Trypsin-activated complex of human factor B with cobra venom factor (CVF), cleaving C3 and C5 and generating a lytic factor for unsensitized guinea pig erythrocytes. I. Generation of the activated complex.人补体B因子与眼镜蛇毒因子（CVF）的胰蛋白酶激活复合物，可裂解C3和C5，并产生针对未致敏豚鼠红细胞的溶血因子。I. 激活复合物的产生。
Biken J. 1975 Dec;18(4):193-204.
9
Human factor D of the alternative complement pathway: purification and characterization.补体替代途径的人因子D：纯化与特性鉴定。
J Immunol. 1977 Jul;119(1):337-42.
10
Humoral immunostimulation. IV. Role of complement.体液免疫刺激。IV. 补体的作用。
J Exp Med. 1975 Apr 1;141(4):736-52.

引用本文的文献

1
Evidence for intrathecal synthesis of alternative pathway complement activation proteins in experimental meningitis.实验性脑膜炎中鞘内合成替代途径补体激活蛋白的证据。
Am J Pathol. 1997 Oct;151(4):897-904.
2
Studies on the possible involvement of complement component C3 in the initiation of acid hydrolase secretion by macrophages. I. Correlation between enzyme-releasing and complement-activating capacities of several secretagogues.关于补体成分C3可能参与巨噬细胞酸性水解酶分泌起始过程的研究。I. 几种促分泌剂的酶释放能力与补体激活能力之间的相关性。
Immunology. 1981 Sep;44(1):29-39.
3
Plasma membrane polypeptides of resident and activated mouse peritoneal macrophages.
驻留和活化的小鼠腹腔巨噬细胞的质膜多肽
Proc Natl Acad Sci U S A. 1980 Apr;77(4):2188-91. doi: 10.1073/pnas.77.4.2188.
4
Murine complement factor B (BF): sexual dimorphism and H-2-linked polymorphism.小鼠补体因子B（BF）：性别二态性与H-2连锁多态性
Immunogenetics. 1982 Jan;15(1):23-30. doi: 10.1007/BF00375499.
5
Isolation and characterization of rat complement factor B and its interaction with cell-bound human C3.大鼠补体因子B的分离、特性鉴定及其与细胞结合的人C3的相互作用
Immunology. 1980 Dec;41(4):849-55.
6
Structural polymorphism of murine factor B controlled by a locus closely linked to the H-2 complex and demonstration of multiple alleles.由与H-2复合体紧密连锁的基因座控制的小鼠B因子的结构多态性及多个等位基因的证明。
Immunogenetics. 1983;18(2):117-24. doi: 10.1007/BF00368539.
7
Solid phase activation of alternative pathway of complement by beta-1,3-glucans and its possible role for tumour regressing activity.β-1,3-葡聚糖对补体替代途径的固相激活及其在肿瘤消退活性中的可能作用。
Immunology. 1978 Apr;34(4):695-705.
8
Insoluble polyanions as activators of both pathways of complement.不溶性多阴离子作为补体两条途径的激活剂。
Immunology. 1977 Dec;33(6):827-37.
9
Regulation of macrophage migration by products of the complement system.补体系统产物对巨噬细胞迁移的调节。
Proc Natl Acad Sci U S A. 1979 Feb;76(2):888-91. doi: 10.1073/pnas.76.2.888.
10
Intense tumour-cell destruction by syngeneic mice: role of macrophages, complement activation and tumour-cell factors.同基因小鼠对肿瘤细胞的强烈破坏作用：巨噬细胞、补体激活及肿瘤细胞因子的作用
Br J Cancer. 1977 Dec;36(6):743-50. doi: 10.1038/bjc.1977.257.