压力和玉米淀粉对片剂崩解时间的影响。
Effect of compression force and corn starch on tablet disintegration time.
作者信息
Hill P M
出版信息
J Pharm Sci. 1976 Nov;65(11):1694-7. doi: 10.1002/jps.2600651134.
PMID:994005
Abstract
An unusual occurrence of decreasing tablet disintegration time with increasing tablet hardness was explored. Tablets were made with varying ratios of starch disintegrant to starch paste and compressed with eight different forces. This unusual disintegration pattern is modified by changes in the starch ratios. The reason for this phenomenon is ascribed to gain swelling as the mechanism by which starch acts as a disintegrant.
摘要
对片剂硬度增加但崩解时间却缩短这一不寻常现象进行了探究。制备了淀粉崩解剂与淀粉浆比例不同的片剂，并使用八种不同压力进行压制。淀粉比例的变化改变了这种不寻常的崩解模式。这种现象的原因归因于淀粉作为崩解剂起作用的机制——膨胀作用。
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