Atkin N B
J Natl Cancer Inst. 1976 May;56(5):909-10. doi: 10.1093/jnci/56.5.909.
The 5-year survival rates of 540 patients with carcinoma of the cervix and 186 with carcinoma of the corpus uteri were assessed in relation to the modal DNA values of the tumors. Patients with squamous cell cervical carcinomas had more favorable prognoses if the modes were near-triploid or hypotetraploid; however, these high-ploidy tumors included more stage III cases than did the tumors with near-diploid modes. Patients with near-diploid endometrial carcinomas has considerably more favorable prognosis than did patients with the minority of tumors at this site, who had high modes; this prognostic difference was only partly related to a higher proportion of poorly differentiated tumors in the high-ploidy group since, among the poorly differentiated tumors, individuals with near-diploid modes again had significantly better prognoses than those with high modes.
对540例宫颈癌患者和186例子宫体癌患者的5年生存率进行了评估，评估内容与肿瘤的众数DNA值相关。如果众数接近三倍体或亚四倍体，宫颈鳞状细胞癌患者的预后更有利；然而，这些高倍体肿瘤比众数接近二倍体的肿瘤包含更多的III期病例。众数接近二倍体的子宫内膜癌患者的预后明显比该部位少数众数高的肿瘤患者更有利；这种预后差异仅部分与高倍体组中低分化肿瘤比例较高有关，因为在低分化肿瘤中，众数接近二倍体的个体的预后再次显著优于众数高的个体。
