Effect of lead on glycine cleavage activity in rat liver mitochondria.

Change of glycine cleavage activity in liver mitochondria of lead-intoxicated rats was studied in this paper. The following results were obtained: (1) The activity in hepatic mitochondria of rats was decreased by a single administration of lead (4 mg/100 g body weight); (2) in vitro the activity in the normal rat liver mitochondria was markedly inhibited by addition of lead acetate (4mM).