Hu Y, Zhang Q
Research Unit of Molecular Toxicology,Sun Yat-Sen University of Medical Sciences, Guangzhou, Guangdong, 510089 P. R. China.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 1999 Feb 10;16(1):26-8.
To assess the possible association between the polymorphisms of CYP1A1 and the susceptibility of lung cancer so as to provide clues for genetic markers of lung cancer.
CYP1A1 rare genotypes MspI C and VV were detected with the methods of PCR-RFLP and ASA in a case-control study including 59 cases of lung cancer, 59 hospital controls and 73 healthy controls.
The frequencies of rare genotypes C and VV of the lung cancer cases were not significantly different from those of the controls, though the frequency of C(25.4%) of the lung cancer cases was higher than that (16.5%) of the controls. However, in the non-smoking group with genotype(C),the risk of lung cancers was 2.43-2.91 times greater than that of the controls. Heterozygote B was overpresented in healthy controls (61.6%),compared to that of lung cancer cases(37.3%), P <0.01,odds ratio 0.37 (95% confidence interval 0.17-0.80).
Genotype C may be one of the susceptibly genetic markers of lung cancer in the non-smoking population. The risk of lung cancer can be decreased in persons with heterozygote.
评估细胞色素P450 1A1（CYP1A1）基因多态性与肺癌易感性之间的可能关联，为肺癌的遗传标志物提供线索。
采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）和等位基因特异性扩增（ASA）方法，对59例肺癌患者、59例医院对照和73例健康对照进行CYP1A1罕见基因型MspI C和VV检测。
肺癌患者中罕见基因型C和VV的频率与对照组相比无显著差异，尽管肺癌患者中C（25.4%）的频率高于对照组（16.5%）。然而，在基因型为（C）的非吸烟组中，肺癌风险是对照组的2.43 - 2.91倍。与肺癌患者（37.3%）相比，杂合子B在健康对照中占比过高（61.6%），P <0.01，优势比为0.37（95%置信区间0.17 - 0.80）。
基因型C可能是非吸烟人群中肺癌的易感遗传标志物之一。杂合子个体患肺癌风险可能降低。
