Falkenhagen D, Strobl W, Vogt G, Schrefl A, Linsberger I, Gerner F J, Schoenhofen M
Center of Biomedical Technology, Danube University Krems, Austria.
Artif Organs. 1999 Jan;23(1):81-6. doi: 10.1046/j.1525-1594.1999.06292.x.
The removal of albumin bound substances has gained increasing interest in different diseases, especially in acute and chronic liver disease. Therefore, a new system, the fractionated plasma separation and adsorption (FPSA) system, was developed based on combined membrane and adsorbent blood purification techniques. The most important contribution to the FPSA system was the development of a new polysulfone hollow-fiber filter, which is characterized by a sieving coefficient of 0.89 for human serum albumin (HSA) but only of 0.17 for fibrinogen, and 0 (zero) for IgM immunoglobulins. Using a closed filtrate circuit connected to the new polysulfone filter which integrates 1 or 2 adsorption columns and also a high flux dialyzer adapted to a dialysis machine, the FPSA system opens excellent possibilities for the relatively specific removal of albumin bound substances from the blood such as albumin bound bilirubin or even tryptophan. In comparison to other systems (for example, the Molecular Adsorbent Recirculating System [MARS] and albumin dialysis systems), the FPSA system enables much higher elimination of strongly bound albumin substances. The first clinical investigations have recently started based on a modified dialysis machine designed with all necessary safety measures.
去除与白蛋白结合的物质在不同疾病中越来越受到关注，尤其是在急慢性肝病中。因此，基于膜和吸附剂血液净化技术的结合，开发了一种新的系统——分级血浆分离吸附（FPSA）系统。对FPSA系统最重要的贡献是开发了一种新的聚砜中空纤维滤器，其对人血清白蛋白（HSA）的筛分系数为0.89，而对纤维蛋白原仅为0.17，对IgM免疫球蛋白为0（零）。通过使用连接到新聚砜滤器的封闭滤液回路，该回路集成了1个或2个吸附柱以及一个适用于透析机的高通量透析器，FPSA系统为从血液中相对特异性地去除与白蛋白结合的物质（如与白蛋白结合的胆红素甚至色氨酸）提供了极好的可能性。与其他系统（例如分子吸附循环系统 [MARS] 和白蛋白透析系统）相比，FPSA系统能够更高程度地清除与白蛋白紧密结合的物质。最近，基于配备了所有必要安全措施的改良透析机，首次开展了临床研究。
