Akberova S I, Musaev Galbinur P I, Magomedov N M, Babaev Kh F, Gakhramanov Kh M, Stroeva O G
Vestn Oftalmol. 1998 Nov-Dec;114(6):39-44.
Effect of para-aminobenzoic acid (PABA) on lipid peroxidation (LPO) in rat and guinea pig retina exposed to hypoxic hypoxia is studied. PABA was injected intraperitoneally and parabulbarly before and after hypoxic exposure. Antioxidant activities of PABA and emoxipin were compared. An intraperitoneal injection of PABA in a dose of 10 mg/kg 24 h before hypoxia virtually completely prevented accumulation of lipid peroxides and preserved catalase activity in the retina. Parabulbar injection of 0.01% PABA solution 1 h before hypoxia prevented LPO intensification, stabilized catalase activity in hypoxia, and protected the retina starting from the moment immediately after hypoxic exposure. The efficacy of 0.01% PABA is comparable with that of 1% emoxipin, and a 0.01% solution of emoxipin is less effective than PABA in the same concentration. PABA exerts an antioxidant effect after hypoxia by decreasing the abnormally high level of lipid peroxides and reducing catalase activity in the retina after parabulbar injection of the drug. All the studied concentrations of the drug (from 0.007 to 0.08%) are active, but the optimal dose for the retina is 0.04%. By its efficacy this concentration is equivalent to 1% emoxipin.
研究了对氨基苯甲酸（PABA）对暴露于低氧性缺氧的大鼠和豚鼠视网膜脂质过氧化（LPO）的影响。在低氧暴露前后，分别经腹腔和球后注射PABA。比较了PABA和艾莫昔平的抗氧化活性。在缺氧前24小时腹腔注射10mg/kg剂量的PABA，几乎完全阻止了视网膜中脂质过氧化物的积累，并保留了过氧化氢酶活性。在缺氧前1小时球后注射0.01%PABA溶液，可防止LPO增强，稳定缺氧时的过氧化氢酶活性，并从缺氧暴露后即刻起保护视网膜。0.01%PABA的疗效与1%艾莫昔平相当，且相同浓度下0.01%艾莫昔平溶液的效果不如PABA。球后注射该药物后，PABA通过降低视网膜中脂质过氧化物的异常高水平和降低过氧化氢酶活性，在缺氧后发挥抗氧化作用。所有研究浓度的该药物（从0.007%到0.08%）均有活性，但对视网膜的最佳剂量为0.04%。就其疗效而言，该浓度相当于1%艾莫昔平。
