Hori S, Yamaguchi Y, Shimizu H
Faculty of Pharmaceutical Sciences, Tokyo University, Japan.
Biol Cybern. 1999 Jan;80(1):1-10. doi: 10.1007/s004220050500.
To elucidate the mechanism of the self-organizing control of heartbeats, models that include the electrical and mechanical processes of heartbeat are proposed. As the mutual interaction between the two processes, mechano-electrical feedback (MEF), mediated by stretch-activated ionic channels, is considered. Analyses of the models show that coordination of beats among myocardial cells is established by MEF even in the absence of electrical coupling. The coordination of heartbeats is found to show in-phase synchronization under normal conditions, while it is out of phase or irregular under mechanically abnormal conditions. It is concluded that coupling by MEF is important for the self-organization of heartbeats.
为阐明心跳自组织控制的机制，提出了包含心跳电过程和机械过程的模型。作为这两个过程之间的相互作用，由牵张激活离子通道介导的机械电反馈（MEF）被考虑在内。对模型的分析表明，即使在没有电耦合的情况下，心肌细胞之间的搏动协调也可通过MEF建立。研究发现，在正常情况下，心跳协调表现为同相同步，而在机械异常情况下则为异相或不规则。得出的结论是，MEF耦合对心跳的自组织很重要。
