Jaakkola A, Vesti E, Immonen I
Department of Ophthalmology, Helsinki University Central Hospital, Finland.
Ophthalmology. 1999 Feb;106(2):274-9. doi: 10.1016/S0161-6420(99)90065-9.
To evaluate the feasibility of using confocal scanning laser tomography in the analysis of macular topography in patients with subfoveal choroidal neovascularization associated with age-related macular degeneration (AMD) and to analyze quantitatively the changes in topography after local strontium-plaque radiation therapy.
Prospective case series.
A total of 16 eyes with subfoveal choroidal neovascular membranes (CNVM) treated with strontium-90 (90Sr)-plaque radiation therapy and 16 fellow eyes of 16 patients were examined.
Confocal scanning laser analysis of macular surface topography before and after irradiation of the macula was performed.
Parameters describing the height and volume of the retinal elevation in the macula were measured.
The maximum height of the macular lesion at baseline was 0.25 mm (standard deviation [SD], 0.12 mm) in eyes showing regression of the CNVM during follow-up and 0.34 mm (SD, 0.19 mm) in eyes showing continued growth of the CNVM. During follow-up, a mean decrease in the maximum height of the macular lesion ranging from 0.03 to 0.10 mm occurred in eyes with regression of the CNVM, whereas the mean maximum height increased by 0.07 to 0.15 mm during follow-up visits in eyes with continued growth of the CNVM. All parameters describing the mean height and volume of the lesion also decreased significantly in patients showing angiographic regression, whereas they increased or remained unchanged in patients with continuous growth of the CNVM despite irradiation. The corresponding parameters also were higher in fellow eyes with untreated CNVM than in eyes without exudative AMD.
Confocal scanning laser tomography can be used to monitor the amount of the change in neurosensory detachment in AMD. The parameters obtained by confocal scanning laser tomography correlate with CNVM perfusion after 90Sr-plaque radiation therapy. This technology is a useful tool for objective evaluation of morphologic change after institution of new therapeutic methods for the treatment of AMD.
评估共焦扫描激光断层扫描技术用于分析年龄相关性黄斑变性（AMD）所致黄斑下脉络膜新生血管患者黄斑地形图的可行性，并定量分析局部锶斑块放射治疗后地形图的变化。
前瞻性病例系列研究。
对16只接受锶-90（90Sr）斑块放射治疗的黄斑下脉络膜新生血管膜（CNVM）患眼及16例患者的16只对侧眼进行检查。
对黄斑照射前后进行黄斑表面地形图的共焦扫描激光分析。
测量描述黄斑区视网膜隆起高度和体积的参数。
随访期间CNVM消退的患眼中，黄斑病变的基线最大高度为0.25mm（标准差[SD]，0.12mm）；CNVM持续生长的患眼中，黄斑病变的基线最大高度为0.34mm（SD，0.19mm）。随访期间，CNVM消退的患眼中黄斑病变最大高度平均下降0.03至0.10mm，而CNVM持续生长的患眼中黄斑病变最大高度在随访期间平均增加0.07至0.15mm。在血管造影显示消退的患者中，所有描述病变平均高度和体积的参数也显著下降，而在CNVM持续生长的患者中，尽管进行了照射，这些参数仍增加或保持不变。未经治疗的CNVM对侧眼中的相应参数也高于无渗出性AMD的患眼。
共焦扫描激光断层扫描可用于监测AMD中神经感觉脱离的变化量。共焦扫描激光断层扫描获得的参数与90Sr斑块放射治疗后的CNVM灌注相关。该技术是客观评估AMD新治疗方法实施后形态学变化的有用工具。
