Sachse C, Jahns-Streubel G, Henkel E
Department of Clinical Chemistry II, Medical School Hannover, Germany.
Clin Lab Haematol. 1998 Dec;20(6):333-40. doi: 10.1046/j.1365-2257.1998.00172.x.
A prototype of the CELL-DYN 3200 haematology analyser was evaluated in a tertiary care hospital laboratory. Precision, effects of sample ageing, linearity, carry-over, and comparability of cellular blood counts and five-part leucocyte differentiation were determined in accordance with the ICSH guidelines for the evaluation of blood cell analysers; the results were satisfactory for all parameters tested: haemoglobin concentration, RBC, MCV, WBC, platelet count, and counts of neutrophils, lymphocytes, monocytes, and eosinophils. Two-hundred and forty-seven routine blood samples were used for the comparability studies. The cellular blood count results from the CELL-DYN 3200 and the Bayer Diagnostic H-1 systems corresponded closely (correlation coefficient r > 0.96 for all parameters). For 201 samples without an instrument-generated suspect flag the same was true with regard to the differential parameters, although somewhat lower correlation was observed for monocyte counts (r = 0.88). Comparisons to 400-cell microscopic differentials gave similar results (r > 0.93 for neutrophil, lymphocyte and eosinophil counts). Our results suggest that the CELL-DYN 3200 analyser will serve the needs for automated blood cell counting and differential leucocyte counting in a tertiary care hospital laboratory.
在一家三级护理医院实验室对CELL-DYN 3200血液分析仪的原型进行了评估。根据国际血液学标准化委员会（ICSH）关于血细胞分析仪评估的指南，测定了精密度、样本老化的影响、线性、携带污染以及血细胞计数和五分类白细胞分化的可比性；所有测试参数的结果均令人满意：血红蛋白浓度、红细胞、平均红细胞体积、白细胞、血小板计数以及中性粒细胞、淋巴细胞、单核细胞和嗜酸性粒细胞计数。247份常规血液样本用于可比性研究。CELL-DYN 3200和拜耳诊断H-1系统的血细胞计数结果密切相关（所有参数的相关系数r>0.96）。对于201份无仪器生成可疑标记的样本，分类参数方面也是如此，尽管单核细胞计数的相关性略低（r = 0.88）。与400细胞显微镜分类计数的比较给出了相似的结果（中性粒细胞、淋巴细胞和嗜酸性粒细胞计数的r>0.93）。我们的结果表明，CELL-DYN 3200分析仪将满足三级护理医院实验室对自动血细胞计数和白细胞分类计数的需求。
