Kubo S, Nishiguchi S, Hirohashi K, Tanaka H, Shuto T, Kinoshita H, Kuroki T
Second Department of Surgery, Osaka City University Medical School, Osaka, Japan.
Hepatogastroenterology. 1998 Nov-Dec;45(24):2252-4.
BACKGROUND/AIMS: GB virus C has been associated with some cases of fulminant hepatitis and post-transfusion hepatitis. We examined transfusion-related infection with this virus.
Of 150 patients undergoing liver resection, 108 received a homologous blood transfusion. Serum samples before and after surgery were examined for GB virus C RNA by a nested polymerase chain reaction with reverse transcription. We also studied the post-operative course of patients infected with GB virus C by blood transfusion.
Viral RNA was detected in sera taken after transfusion in 4 (4%) patients receiving homologous transfusions. Viral RNA was not detected after surgery in the 42 patients given autologous transfusions or not receiving homologous blood. Post-operative courses in the 4 infected patients were uneventful.
As 4% of homologous transfusions resulted in GB virus C infection in our small surgical study, autologous transfusion is recommended when circumstances permit.
背景/目的：GB病毒C与一些暴发性肝炎及输血后肝炎病例有关。我们研究了该病毒的输血相关感染情况。
150例行肝切除术的患者中，108例接受了同源输血。术前及术后血清样本通过逆转录巢式聚合酶链反应检测GB病毒C RNA。我们还研究了因输血感染GB病毒C的患者的术后病程。
接受同源输血的患者中，4例（4%）输血后血清中检测到病毒RNA。42例接受自体输血或未接受同源输血的患者术后未检测到病毒RNA。4例感染患者的术后病程平稳。
在我们的小型外科研究中，4%的同源输血导致了GB病毒C感染，因此在条件允许时建议采用自体输血。
