肝手术期间及术后输血导致的GB病毒C感染

GB virus C infection by blood transfusion during and following liver surgery.

作者信息

Kubo S, Nishiguchi S, Hirohashi K, Tanaka H, Shuto T, Kinoshita H, Kuroki T

机构信息

Second Department of Surgery, Osaka City University Medical School, Osaka, Japan.

出版信息

Hepatogastroenterology. 1998 Nov-Dec;45(24):2252-4.

PMID:9951905

Abstract

BACKGROUND/AIMS: GB virus C has been associated with some cases of fulminant hepatitis and post-transfusion hepatitis. We examined transfusion-related infection with this virus.

METHODOLOGY

Of 150 patients undergoing liver resection, 108 received a homologous blood transfusion. Serum samples before and after surgery were examined for GB virus C RNA by a nested polymerase chain reaction with reverse transcription. We also studied the post-operative course of patients infected with GB virus C by blood transfusion.

RESULTS

Viral RNA was detected in sera taken after transfusion in 4 (4%) patients receiving homologous transfusions. Viral RNA was not detected after surgery in the 42 patients given autologous transfusions or not receiving homologous blood. Post-operative courses in the 4 infected patients were uneventful.

CONCLUSIONS

As 4% of homologous transfusions resulted in GB virus C infection in our small surgical study, autologous transfusion is recommended when circumstances permit.

摘要

背景/目的：GB病毒C与一些暴发性肝炎及输血后肝炎病例有关。我们研究了该病毒的输血相关感染情况。