Shimizu A, Koyama M, Okuda Y, Takase K, Nakano T, Tameda Y
Department of Internal Medicine I, Mie University School of Medicine, Tsu, Japan.
Hepatogastroenterology. 1998 Nov-Dec;45(24):2352-5.
We present a 66 year-old woman in the cirrhotic stage of primary biliary cirrhosis (PBC), who developed hepatocellular carcinoma (HCC). All serological tests for hepatitis B virus (HBV) and hepatitis C virus (HCV) were negative. We surveyed 16 reported cases (13 females and 3 males) of PBC associated with HCC in Japan. The presence of HCV RNA was determined by the polymerase chain reaction in all of the patients, 3 of whom (19%) were HCV RNA-positive. Although patients with PBC rarely develop HCC, it is suggested that HCV infection may play a minor role in the development of HCC in Japanese patients with PBC.
我们报告了一名66岁处于原发性胆汁性肝硬化（PBC）肝硬化阶段且发生肝细胞癌（HCC）的女性。所有乙肝病毒（HBV）和丙肝病毒（HCV）的血清学检测均为阴性。我们调查了日本16例报告的PBC合并HCC病例（13例女性和3例男性）。所有患者均通过聚合酶链反应检测HCV RNA的存在，其中3例（19%）HCV RNA呈阳性。尽管PBC患者很少发生HCC，但提示HCV感染在日本PBC患者发生HCC过程中可能起较小作用。
