Qian L, Peters L J, Chen J D
Lynn Institute for Healthcare Research, VA Hospital, Oklahoma City, Oklahoma 73112, USA.
Dig Dis Sci. 1999 Jan;44(1):56-62. doi: 10.1023/a:1026645931867.
The aim-of this study was to investigate the characteristics of the gastric slow wave during different phases of the migrating myoelectrical complex (MMC) and the effect of electroacupuncture on the MMC. The experiment was performed in eight hound dogs implanted with one pair of bipolar serosal electrodes 2 cm proximal to the pylorus. Gastric myoelectrical activity was recorded for three complete cycles of the MMC in two sessions, one with electroacupuncture at points ST36 and PC6 and the other at sham points. The acupuncture was performed for 30 min in phase I of the second cycle of the MMC. Spectral analysis was performed to compute the frequency and power (amplitude) of the gastric slow wave, whereas blind visual analysis was applied to compute the appearance of spike potentials and the length of each phase of the MMC. It was found that there was a significant difference in the frequency and power of the gastric slow wave during different phases of the MMC (P < 0.05). Phase I was characterized with the highest frequency and lowest power of the gastric slow wave, whereas phase III exhibited the highest power in the slow wave. It was also found that in comparison with the sham points, electroacupuncture at the acupoints increased the number of spike bursts. This increase was not significant during the MMC cycle with electroacupuncture (34.4+/-4.1 vs 27.5+/-2.5%, P > 0.05) but became significant during the cycle after electroacupuncture (39.8+/-3.3% vs 27.5+/-2.5%, P < 0.0005). Similarly, during the MMC cycle after electroacupuncture at the acupoints, there was a significant decrease in the length of phase I (14.8+/-2.2 vs 46.9+/-6.1 min, P < 0.003) and a significant increase in the length of phase II (75.6+/-9.9 vs 30.6+/-4.1 min, P < 0.003) and phase III (25.8+/-0.6 vs 22.1+/-0.7 min, P < 0.003). A similar increase was observed during the MMC cycle with electroacupuncture but was not statistically significant. In conclusion, the gastric slow wave has the highest power during phase III of the MMC, indicating that the antral contraction is characterized not only by the appearance of spikes, but also by the increased power of the slow wave. Electroacupuncture at acupoints of ST36 and PC6 enhances the gastric MMC by reducing the length of phase I and increasing the length of phases II and III.
本研究旨在探讨移行性复合肌电（MMC）不同阶段胃慢波的特征以及电针对MMC的影响。实验在8只植入了一对位于幽门近端2 cm处的双极浆膜电极的猎犬身上进行。分两个阶段记录MMC三个完整周期的胃肌电活动，一个阶段针刺足三里（ST36）和内关（PC6）穴位，另一个阶段针刺假穴位。在MMC第二个周期的I期进行30分钟的针刺。采用频谱分析计算胃慢波的频率和功率（振幅），同时采用盲法视觉分析计算棘波电位的出现情况以及MMC各阶段的时长。结果发现，MMC不同阶段胃慢波的频率和功率存在显著差异（P < 0.05）。I期胃慢波频率最高但功率最低，而III期慢波功率最高。还发现，与假穴位相比，针刺穴位增加了棘波爆发的次数。在针刺的MMC周期内这种增加不显著（34.4±4.1%对27.5±2.5%，P > 0.05），但在针刺后的周期变得显著（39.8±3.3%对27.5±2.5%，P < 0.0005）。同样，在针刺穴位后的MMC周期内，I期时长显著缩短（14.8±2.2对46.9±6.1分钟，P < 0.003），II期时长显著增加（75.6±9.9对30.6±4.1分钟，P < 0.003），III期时长也显著增加（25.8±0.6对22.1±0.7分钟，P < 0.003）。在针刺的MMC周期内观察到类似增加，但无统计学意义。总之，胃慢波在MMC的III期功率最高，表明胃窦收缩不仅以棘波出现为特征，还以慢波功率增加为特征。针刺足三里和内关穴位通过缩短I期时长和增加II期及III期时长来增强胃MMC。
