Guillet C, Auguste P, Mayo W, Kreher P, Gascan H
Institut National de la Santé et de la Recherche Médicale (INSERM) CJF 97-08, Centre Hospitalier Universitaire Angers, 49033 Angers Cedex, France.
J Neurosci. 1999 Feb 15;19(4):1257-62. doi: 10.1523/JNEUROSCI.19-04-01257.1999.
Ciliary neurotrophic factor (CNTF) participates in the survival of motor neurons and reduces the denervation-induced atrophy of skeletal muscles. Experiments performed in rats show a decrease in peripheral CNTF synthesis during aging, associated with an overexpression of its alpha-binding receptor component by skeletal muscles. Measurement of sciatic nerve CNTF production and of the muscular performance developed by the animals revealed a strong correlation between the two studied parameters (r = 0.8; p < 0.0003). Furthermore, the twitch and tetanic tensions measured in the isolated soleus skeletal muscle in 24-month-old animals increased 2. 5-fold by continuous in vivo administration of CNTF. Analyses of the activation level of leukemia inhibitory factor receptor beta- and signal transducer and activator of transcription 3-signaling molecules in response to exogenous CNTF revealed an increased tyrosine phosphorylation positively correlated with the twitch tension developed by the soleus muscle of the animals.
睫状神经营养因子（CNTF）参与运动神经元的存活，并减少去神经支配引起的骨骼肌萎缩。在大鼠身上进行的实验表明，衰老过程中外周CNTF合成减少，同时骨骼肌中其α-结合受体成分过度表达。对坐骨神经CNTF产生量以及动物肌肉性能的测量结果显示，两个研究参数之间存在很强的相关性（r = 0.8；p < 0.0003）。此外，通过对24月龄动物连续进行体内给予CNTF，在分离的比目鱼肌中测量到的单收缩和强直张力增加了2.5倍。对外源性CNTF应答时白血病抑制因子受体β及信号转导和转录激活因子3信号分子的激活水平分析显示，酪氨酸磷酸化增加，且与动物比目鱼肌产生的单收缩张力呈正相关。
