Marshall W A
Postgrad Med J. 1976 Oct;52(612):620-4. doi: 10.1136/pgmj.52.612.620.
The production of gonadal steroids in the perinatal period may have an important influence on the later development of the hypothalamo-pituitary-gonadal axis. In the prepubertal period there is an increased output of gonadal steroids and of androgens from the adrenal cortex, with a further increase as the secondary sex characters develop. The precise role of individual steroids in the maturation of the reproductive system and of the neuroendocrine regulating mechanisms will probably remain unclear unless conclusions are based on longitudinal studies in which hormone production is related precisely to different parameters of sexual development and somatic growth.
围产期性腺类固醇的产生可能对下丘脑 - 垂体 - 性腺轴的后期发育有重要影响。在青春期前,性腺类固醇和肾上腺皮质雄激素的分泌增加,随着第二性征的发育进一步增加。除非结论基于纵向研究,即激素产生与性发育和身体生长的不同参数精确相关,否则个别类固醇在生殖系统成熟和神经内分泌调节机制中的精确作用可能仍不清楚。