Kornblith C L, Hoebel B G
Pharmacol Biochem Behav. 1976 Aug;5(2):215-8. doi: 10.1016/0091-3057(76)90039-3.
A comparison was made of the short-term effects in rats of 3 anorectic drugs (amphetamine, fenfluramine, and phenylpropanolamine) on food intake and responses to obtain brain stimulation and to escape from automatic brain stimulation. At a dose which decreased food intake, amphetamine increased self-stimulation, but not stimulation-escape. Fenfluramine decreased both self-stimulation and stimulation-escape. Phenylpropanolamine, on the other hand, decreased self-stimulation, but not stimulation-escape. Even though all 3 drugs decreased food intake, each of them had different effects on hypothalamic self-stimulation and stimulation-escape. Only the actions of phenylpropanolamine were in agreement with the hypothesis that lateral hypothalamic reward and aversion reflect the animal's tendency to eat, suggesting that other aspects of reinforcement are also involved in lateral hypothalamic stimulation and were affected differently by these drugs.
对3种食欲抑制药物（苯丙胺、芬氟拉明和去甲麻黄碱）对大鼠食物摄入量以及获取脑刺激和逃避自动脑刺激反应的短期影响进行了比较。在降低食物摄入量的剂量下，苯丙胺增加了自我刺激，但未增加刺激逃避。芬氟拉明降低了自我刺激和刺激逃避。另一方面，去甲麻黄碱降低了自我刺激，但未降低刺激逃避。尽管这3种药物都降低了食物摄入量，但它们对下丘脑自我刺激和刺激逃避的影响各不相同。只有去甲麻黄碱的作用与下丘脑外侧奖赏和厌恶反映动物进食倾向的假设一致，这表明强化的其他方面也参与了下丘脑外侧刺激，并且受到这些药物的不同影响。
