Bridges P K, Bartlett J R, Sepping P, Kantamaneni B D, Curzon G
Psychol Med. 1976 Aug;6(3):399-405. doi: 10.1017/s003329170001583x.
Tryptophan and 5-hydroxyindoleacetic acid (precursor and metabolite respectively of 5-hydroxytryptamine) were determined in ventricular CSF of psychiatric patients undergoing stereotactic subcaudate tractotomy. Tyrosine and homovanillic acid (precursor and metabolite respectively of dopamine) were also determined. Results suggest an association between affective state and the above precursor amino acids with lower concentrations in primary depression and higher ones when anxiety or agitation predominate. This leads to lower 5-hydroxyindoleacetic acid concentrations in depression and higher concentrations in anxiety and agitation.
对接受立体定向尾状核下束切断术的精神科患者的脑室脑脊液中的色氨酸和5-羟吲哚乙酸（分别为5-羟色胺的前体和代谢物）进行了测定。同时还测定了酪氨酸和高香草酸（分别为多巴胺的前体和代谢物）。结果表明，情感状态与上述前体氨基酸之间存在关联，在原发性抑郁症中浓度较低，而在焦虑或躁动占主导时浓度较高。这导致抑郁症中5-羟吲哚乙酸浓度较低，而焦虑和躁动时浓度较高。
