Miller J R, Blake J W, Tobin T
Res Commun Chem Pathol Pharmacol. 1976 Nov;15(3):447-55.
An electron capturing derivative of apomorphine was prepared by incubating the drug with heptafluorobutyric anhydride (HFBA), triethylamine and heat. Mass spectral analysis suggests that HFBA reacts with both phenolic hydroxyl groups on apomorphine to give a derivative detectable at low picogram levels. This method is sufficiently sensitive for pharmacokinetic studies in the horse and is likely applicable to other dopaminergic analogues of apomorphine.
通过将阿扑吗啡与七氟丁酸酐（HFBA）、三乙胺一起孵育并加热，制备了阿扑吗啡的电子捕获衍生物。质谱分析表明，HFBA与阿扑吗啡上的两个酚羟基反应，生成一种在低皮克水平可检测到的衍生物。该方法对马的药代动力学研究具有足够的灵敏度，并且可能适用于阿扑吗啡的其他多巴胺能类似物。
