Soine W H, Hudson J E, Shoulders B A, Smith R V
J Pharm Sci. 1980 Sep;69(9):1040-3. doi: 10.1002/jps.2600690915.
Methods are described for the preparation of [8,9-2H2]apomorphine and [1,3,8,9-2H4]apomorphine based on reaction of apomorphine in trifluoroacetic acid-d. The mass spectral properties of these compounds and of the O,O-bis(heptafluorobutyrate) ester and the O,O-bis(tert-butyldimethylsilyl) ethers of apomorphine, using electron impact and chemical ionization, are reported. [1,3,8,9-2H4]Apomorphine was used to elaborate the 13C-NMR chemical shifts of the proton-bearing carbons of apomorphine.
