Paty J, Brenot P, Henry P, Faure J M
Rev Neurol (Paris). 1976 Sep;132(9):605-21.
A study was carried out of 32 patients suffering from multiple sclerosis the diagnois of which was quite definite according to Mac Alpine's criteria and which had developed over more than two years. Comparison was made with patient suffering from optic neuritis of a different aetiology and with normal subjects. The method of investigation was dynamic electroretinoencephalography : the visual evoked potentials were investigated after stimulation by white and coloured light before and after adapatation to darkness. The specificity of the results was tested by, firstly, electro-retinogram recording for control of the visual system, and secondly, by the recording of auditory evoked potentials for control cerebral function. Abnormalities in visual evoked potentials were found in 77 percent of the cases. In particular, there was delayed latency, that is, a slowing of retino-cortical conduction. The significance of these abnormalities is discussed, by analyzing the electroclinical correlationships according to whether there was obvious or subclinical optic neuritis, and the dissemination, activity or duration of the disease. The incidence of visual evoked potential abnormalities was considerably greater than that in optic neuritis (35 percent). The links between abnormalities in nervous conduction and demyelinisation are emphasized. The role and specificity of electrophysiological investigation in diagnosis of multiple sclerosis are discussed.
对32例多发性硬化症患者进行了一项研究，这些患者的诊断根据麦克阿尔平标准相当明确，且病程超过两年。将其与患有不同病因视神经炎的患者以及正常受试者进行了比较。研究方法是动态视网膜电图：在适应黑暗前后，用白光和彩色光刺激后对视诱发电位进行研究。结果的特异性首先通过记录视网膜电图来控制视觉系统，其次通过记录听觉诱发电位来控制脑功能进行测试。77%的病例发现视诱发电位异常。特别是，存在潜伏期延迟，即视网膜-皮质传导减慢。通过根据是否存在明显或亚临床视神经炎以及疾病的播散、活动或病程分析电临床相关性，讨论了这些异常的意义。视诱发电位异常的发生率明显高于视神经炎患者（35%）。强调了神经传导异常与脱髓鞘之间的联系。讨论了电生理检查在多发性硬化症诊断中的作用和特异性。
