• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Group D adenoviruses infect primary central nervous system cells more efficiently than those from group C.D组腺病毒比C组腺病毒更有效地感染原发性中枢神经系统细胞。
J Virol. 1999 Mar;73(3):2537-40. doi: 10.1128/JVI.73.3.2537-2540.1999.
2
Tropism modification of adenovirus vectors by peptide ligand insertion into various positions of the adenovirus serotype 41 short-fiber knob domain.通过将肽配体插入腺病毒血清型41短纤维钮结构域的不同位置来修饰腺病毒载体的嗜性。
J Virol. 2007 Mar;81(6):2688-99. doi: 10.1128/JVI.02722-06. Epub 2006 Dec 27.
3
A chimeric type 2 adenovirus vector with a type 17 fiber enhances gene transfer to human airway epithelia.一种带有17型纤维的嵌合2型腺病毒载体可增强基因向人呼吸道上皮细胞的转移。
J Virol. 1999 Oct;73(10):8689-95. doi: 10.1128/JVI.73.10.8689-8695.1999.
4
Alternate adenovirus type-pairs for a possible circumvention of host immune response to recombinant adenovirus vectors.
Acta Microbiol Immunol Hung. 2001;48(2):143-6.
5
Human adenovirus serotypes 4p and 11p are efficiently expressed in cell lines of neural tumour origin.人腺病毒血清型4p和11p在神经肿瘤来源的细胞系中高效表达。
J Gen Virol. 2002 Jun;83(Pt 6):1299-1309. doi: 10.1099/0022-1317-83-6-1299.
6
"Sero-switch" adenovirus-mediated in vivo gene transfer: circumvention of anti-adenovirus humoral immune defenses against repeat adenovirus vector administration by changing the adenovirus serotype.“血清型转换”腺病毒介导的体内基因转移：通过改变腺病毒血清型规避针对重复腺病毒载体给药的抗腺病毒体液免疫防御。
Hum Gene Ther. 1996 Jan;7(1):79-87. doi: 10.1089/hum.1996.7.1-79.
7
Efficient mobilization of E1-deleted adenovirus type 5 vectors by wild-type adenoviruses of other serotypes.其他血清型野生型腺病毒对E1缺失的5型腺病毒载体的高效动员
J Gen Virol. 2002 Jun;83(Pt 6):1311-1314. doi: 10.1099/0022-1317-83-6-1311.
8
Induction of endogenous genes following infection of human endothelial cells with an E1(-) E4(+) adenovirus gene transfer vector.用E1(-)E4(+)腺病毒基因转移载体感染人内皮细胞后内源性基因的诱导
J Virol. 1999 Dec;73(12):10183-90. doi: 10.1128/JVI.73.12.10183-10190.1999.
9
Construction and characterization of hexon-chimeric adenoviruses: specification of adenovirus serotype.六邻体嵌合腺病毒的构建与特性：腺病毒血清型的确定
J Virol. 1998 Dec;72(12):10260-4. doi: 10.1128/JVI.72.12.10260-10264.1998.
10
Evolution and Cryo-electron Microscopy Capsid Structure of a North American Bat Adenovirus and Its Relationship to Other Mastadenoviruses.一种北美蝙蝠腺病毒的进化、冷冻电镜衣壳结构及其与其他哺乳动物腺病毒的关系
J Virol. 2017 Jan 3;91(2). doi: 10.1128/JVI.01504-16. Print 2017 Jan 15.

引用本文的文献

1
Viral vector-based tools advance knowledge of basal ganglia anatomy and physiology.基于病毒载体的工具推动了对基底神经节解剖学和生理学的认识。
J Neurophysiol. 2016 Apr;115(4):2124-46. doi: 10.1152/jn.01131.2015. Epub 2016 Feb 17.
2
Vascular targeting: recent advances and therapeutic perspectives.血管靶向：最新进展与治疗前景
Trends Cardiovasc Med. 2006 Apr;16(3):80-8. doi: 10.1016/j.tcm.2006.01.003.
3
Transductional targeting of adenovirus vectors for gene therapy.用于基因治疗的腺病毒载体的转导靶向
Cancer Gene Ther. 2006 Sep;13(9):830-44. doi: 10.1038/sj.cgt.7700928. Epub 2006 Jan 27.
4
General strategy for broadening adenovirus tropism.拓宽腺病毒嗜性的总体策略。
J Virol. 2003 Oct;77(20):11094-104. doi: 10.1128/jvi.77.20.11094-11104.2003.
5
Targeting gene therapy vectors to the vascular endothelium.将基因治疗载体靶向血管内皮细胞。
Curr Atheroscler Rep. 2003 May;5(3):163-70. doi: 10.1007/s11883-003-0019-9.
6
Reduction of natural adenovirus tropism to the liver by both ablation of fiber-coxsackievirus and adenovirus receptor interaction and use of replaceable short fiber.通过消融纤维-柯萨奇病毒和腺病毒受体相互作用以及使用可替换的短纤维来降低天然腺病毒对肝脏的嗜性。
J Virol. 2003 Feb;77(4):2512-21. doi: 10.1128/jvi.77.4.2512-2521.2003.
7
Comparative sequence analysis of the largest E1A proteins of human and simian adenoviruses.人类和猿猴腺病毒最大E1A蛋白的比较序列分析
J Virol. 2002 Aug;76(16):7968-75. doi: 10.1128/jvi.76.16.7968-7975.2002.
8
Adenovirus serotype 30 fiber does not mediate transduction via the coxsackie-adenovirus receptor.30型腺病毒纤维蛋白不能通过柯萨奇病毒-腺病毒受体介导转导。
J Virol. 2002 Jan;76(2):656-61. doi: 10.1128/jvi.76.2.656-661.2002.
9
Functional and selective targeting of adenovirus to high-affinity Fcgamma receptor I-positive cells by using a bispecific hybrid adapter.通过使用双特异性杂交衔接子实现腺病毒对高亲和力Fcγ受体I阳性细胞的功能性和选择性靶向。
J Virol. 2001 Jan;75(1):480-9. doi: 10.1128/JVI.75.1.480-489.2001.
10
Dependence of adenovirus infectivity on length of the fiber shaft domain.腺病毒感染性对纤维杆状结构域长度的依赖性。
J Virol. 2000 Nov;74(22):10274-86. doi: 10.1128/jvi.74.22.10274-10286.2000.

本文引用的文献

1
Extensive beta-glucuronidase activity in murine central nervous system after adenovirus-mediated gene transfer to brain.腺病毒介导的基因转移至脑内后小鼠中枢神经系统中广泛的β-葡萄糖醛酸酶活性
Hum Gene Ther. 1998 Nov 1;9(16):2331-40. doi: 10.1089/hum.1998.9.16-2331.
2
Poly (lactic-glycolic) acid copolymer encapsulation of recombinant adenovirus reduces immunogenicity in vivo.重组腺病毒的聚（乳酸-乙醇酸）共聚物包封可降低其体内免疫原性。
Gene Ther. 1998 Jun;5(6):740-6. doi: 10.1038/sj.gt.3300647.
3
Targeted gene delivery by tropism-modified adenoviral vectors.通过嗜性修饰腺病毒载体进行靶向基因递送。
Nat Biotechnol. 1996 Nov;14(11):1574-8. doi: 10.1038/nbt1196-1574.
4
Limited entry of adenovirus vectors into well-differentiated airway epithelium is responsible for inefficient gene transfer.腺病毒载体进入分化良好的气道上皮的能力有限，这导致了基因转移效率低下。
J Virol. 1998 Jul;72(7):6014-23. doi: 10.1128/JVI.72.7.6014-6023.1998.
5
Lack of high affinity fiber receptor activity explains the resistance of ciliated airway epithelia to adenovirus infection.缺乏高亲和力纤维受体活性解释了纤毛气道上皮对腺病毒感染的抗性。
J Clin Invest. 1997 Sep 1;100(5):1144-9. doi: 10.1172/JCI119625.
6
Immune responses to reporter proteins and high viral dose limit duration of expression with adenoviral vectors: comparison of E2a wild type and E2a deleted vectors.对报告蛋白的免疫反应和高病毒剂量限制腺病毒载体的表达持续时间：E2a野生型和E2a缺失载体的比较。
Hum Gene Ther. 1997 Jul 1;8(10):1275-86. doi: 10.1089/hum.1997.8.10-1275.
7
Adenovirus type 5 fiber knob binds to MHC class I alpha2 domain at the surface of human epithelial and B lymphoblastoid cells.5型腺病毒纤维结在人上皮细胞和B淋巴母细胞表面与MHC I类α2结构域结合。
EMBO J. 1997 May 1;16(9):2294-306. doi: 10.1093/emboj/16.9.2294.
8
Selective targeting of human cells by a chimeric adenovirus vector containing a modified fiber protein.一种含有修饰纤维蛋白的嵌合腺病毒载体对人细胞的选择性靶向作用。
J Virol. 1997 Jun;71(6):4782-90. doi: 10.1128/JVI.71.6.4782-4790.1997.
9
Recombinant adenovirus: a gene transfer vector for study and treatment of CNS diseases.重组腺病毒：一种用于中枢神经系统疾病研究与治疗的基因转移载体。
Exp Neurol. 1997 Mar;144(1):125-30. doi: 10.1006/exnr.1996.6398.
10
HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses.HCAR和MCAR：C亚群腺病毒和B组柯萨奇病毒的人类和小鼠细胞受体。
Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3352-6. doi: 10.1073/pnas.94.7.3352.

D组腺病毒比C组腺病毒更有效地感染原发性中枢神经系统细胞。

Group D adenoviruses infect primary central nervous system cells more efficiently than those from group C.

作者信息

Chillon M, Bosch A, Zabner J, Law L, Armentano D, Welsh M J, Davidson B L

机构信息

Howard Hughes Medical Institute, University of Iowa, College of Medicine, Iowa City, Iowa, USA.

出版信息

J Virol. 1999 Mar;73(3):2537-40. doi: 10.1128/JVI.73.3.2537-2540.1999.

DOI:10.1128/JVI.73.3.2537-2540.1999
PMID:9971839
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC104501/
Abstract

Group C adenovirus-mediated gene transfer to central nervous system cells is inefficient. We found that wild-type group D viruses, or recombinant adenovirus type 2 (Ad2) (group C) modified to contain Ad17 (group D) fiber, were more efficient in infecting primary cultures of neurons. Together with studies on primary vascular endothelial cells and tissue culture cell lines, our results indicate that there is not a universally applicable adenovirus serotype for use as a gene transfer vector.

摘要

C组腺病毒介导的基因转移至中枢神经系统细胞的效率低下。我们发现，野生型D组病毒，或经修饰以包含Ad17（D组）纤维的重组2型腺病毒（Ad2，C组），在感染原代神经元培养物方面效率更高。结合对原代血管内皮细胞和组织培养细胞系的研究，我们的结果表明，不存在一种普遍适用的腺病毒血清型可作为基因转移载体。