D组腺病毒比C组腺病毒更有效地感染原发性中枢神经系统细胞。
Group D adenoviruses infect primary central nervous system cells more efficiently than those from group C.
作者信息
Chillon M, Bosch A, Zabner J, Law L, Armentano D, Welsh M J, Davidson B L
机构信息
Howard Hughes Medical Institute, University of Iowa, College of Medicine, Iowa City, Iowa, USA.
出版信息
J Virol. 1999 Mar;73(3):2537-40. doi: 10.1128/JVI.73.3.2537-2540.1999.
Abstract
Group C adenovirus-mediated gene transfer to central nervous system cells is inefficient. We found that wild-type group D viruses, or recombinant adenovirus type 2 (Ad2) (group C) modified to contain Ad17 (group D) fiber, were more efficient in infecting primary cultures of neurons. Together with studies on primary vascular endothelial cells and tissue culture cell lines, our results indicate that there is not a universally applicable adenovirus serotype for use as a gene transfer vector.
摘要
C组腺病毒介导的基因转移至中枢神经系统细胞的效率低下。我们发现，野生型D组病毒，或经修饰以包含Ad17（D组）纤维的重组2型腺病毒（Ad2，C组），在感染原代神经元培养物方面效率更高。结合对原代血管内皮细胞和组织培养细胞系的研究，我们的结果表明，不存在一种普遍适用的腺病毒血清型可作为基因转移载体。
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