Davidson B L, Bohn M C
Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242, USA.
Exp Neurol. 1997 Mar;144(1):125-30. doi: 10.1006/exnr.1996.6398.
Gene transfer to the CNS with recombinant adenoviral vectors is a relatively recent event. In initial reports it was clearly demonstrated that adenoviral vectors can transfer genetic material to multiple cell types within the CNS. The relative ease in generating recombinant adenovirus (Ad) led to feasibility studies in the CNS with application to animal models of inherited disease, neurodegenerative diseases (e.g., Parkinson's and amyotrophic lateral sclerosis), and cerebrovascular disease. In combination with Ad gene transfer to peripheral tissues, these experiments have identified specific limitations and directed further research to improve vector design, formulation, and delivery.
利用重组腺病毒载体将基因转移至中枢神经系统是相对较新的研究进展。在最初的报告中，已明确证实腺病毒载体能够将遗传物质转移至中枢神经系统内的多种细胞类型。生成重组腺病毒（Ad）相对简便，这促使人们在中枢神经系统开展可行性研究，并应用于遗传性疾病、神经退行性疾病（如帕金森病和肌萎缩侧索硬化症）以及脑血管疾病的动物模型。结合将Ad基因转移至外周组织的研究，这些实验已明确了特定的局限性，并引导进一步研究以改进载体设计、制剂和递送方式。
