柯萨奇病毒和腺病毒受体的胞质和跨膜结构域对于柯萨奇病毒和腺病毒感染并非必不可少。
Coxsackievirus and adenovirus receptor cytoplasmic and transmembrane domains are not essential for coxsackievirus and adenovirus infection.
作者信息
Wang X, Bergelson J M
机构信息
Division of Immunologic and Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.
出版信息
J Virol. 1999 Mar;73(3):2559-62. doi: 10.1128/JVI.73.3.2559-2562.1999.
Abstract
Coxsackievirus and adenovirus receptor (CAR) from which the cytoplasmic domain had been deleted and glycosylphosphatidylinositol (GPI)-anchored CAR lacking both transmembrane and cytoplasmic domains were both capable of facilitating adenovirus 5-mediated gene delivery and infection by coxsackievirus B3. These results indicate that the CAR extracellular domain is sufficient to permit virus attachment and entry and that the presence of a GPI anchor does not prevent infection.
摘要
缺失细胞质结构域的柯萨奇病毒和腺病毒受体（CAR）以及既缺乏跨膜结构域又缺乏细胞质结构域的糖基磷脂酰肌醇（GPI）锚定型CAR，都能够促进腺病毒5介导的基因传递以及柯萨奇病毒B3的感染。这些结果表明，CAR细胞外结构域足以允许病毒附着和进入，并且GPI锚的存在并不妨碍感染。
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Adenovirus targeted to heparan-containing receptors increases its gene delivery efficiency to multiple cell types.靶向含硫酸乙酰肝素受体的腺病毒可提高其对多种细胞类型的基因递送效率。
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