Schalla M, Weiss M
Section of Pharmacokinetics, Department of Pharmacology, Martin Luther University Halle-Wittenberg, 06097 Halle, Germany.
Eur J Pharm Sci. 1999 Mar;7(4):305-9. doi: 10.1016/s0928-0987(98)00042-6.
The combination of the nonlinear regression program ADAPT II with Talbot's method of numerical Laplace transformation, that allows parameter estimation when the model function is given only in the Laplace domain, is described and successfully applied to pharmacokinetic problems. The accuracy and precision of the method has been found satisfactory; its performance is comparable to that achieved in parameter estimation based on functions defined in the time domain.
描述了非线性回归程序ADAPT II与塔尔博特数值拉普拉斯变换方法的结合，该方法在模型函数仅在拉普拉斯域给出时允许进行参数估计，并成功应用于药代动力学问题。已发现该方法的准确性和精密度令人满意；其性能与基于时域定义的函数进行参数估计所达到的性能相当。
