Sasamura T, Matsuda A, Kokuba Y
Infusion Research Department, Hoechst Marion Roussel Ltd., Saitama, Japan.
Biosci Biotechnol Biochem. 1998 Dec;62(12):2418-20. doi: 10.1271/bbb.62.2418.
The effects of a D-methionine-containing solution (DMCS) on the nutritional status of AH109A hepatomabearing rats receiving total parenteral nutrition were studied. The DMCS solution inhibited the decrease of transferrin in the plasma of tumor-bearing rats when compared with the effect of an L-methionine-containing solution. The survival time was also significantly prolonged in the DMCS-treated rats. These results indicate that DMCS had a beneficial effect on the malnutrition induced in tumor-bearing rats and would be a useful amino acid solution for the nutritional support of cancer patients.
研究了含D-蛋氨酸溶液（DMCS）对接受全胃肠外营养的AH109A荷肝癌大鼠营养状况的影响。与含L-蛋氨酸溶液的作用相比，DMCS溶液抑制了荷瘤大鼠血浆中转铁蛋白的减少。DMCS处理的大鼠生存时间也显著延长。这些结果表明，DMCS对荷瘤大鼠诱导的营养不良有有益作用，将是一种用于癌症患者营养支持的有用氨基酸溶液。
