Butler A A, Yakar S, Gewolb I H, Karas M, Okubo Y, LeRoith D
Diabetes Branch, National Institutes of Health, Bethesda, MD 20892-1770, USA.
Comp Biochem Physiol B Biochem Mol Biol. 1998 Sep;121(1):19-26. doi: 10.1016/s0305-0491(98)10106-2.
The insulin-like growth factor-I receptor (IGF-IR) mediates the biological actions of IGF-I and IGF-II. The IGFs play a critical role in promoting development, stimulating growth and organogenesis via mitogenic, antiapoptotic and chemotactic activity. Recent research has focused on the events that occur intracellularly upon receptor activation. Several pathways have been shown to be important. The insulin-receptor substrate (IRS), SHC, GRB2, CRKII and CRKL adaptor proteins have all been implicated in transmitting signals to the nucleus of the cell. This review outlines some of the signalling pathways believed to be important in converting IGF-IR activation into changes in cell behavior and metabolism.
胰岛素样生长因子-I受体（IGF-IR）介导IGF-I和IGF-II的生物学作用。IGF通过有丝分裂、抗凋亡和趋化活性在促进发育、刺激生长和器官形成中发挥关键作用。最近的研究集中在受体激活后细胞内发生的事件。已证明几条途径很重要。胰岛素受体底物（IRS）、SHC、GRB2、CRKII和CRKL衔接蛋白都参与将信号传递到细胞核。本综述概述了一些据信在将IGF-IR激活转化为细胞行为和代谢变化中起重要作用的信号通路。
