Nelson D R
Department of Biochemistry, University of Tennessee, Memphis 38163, USA.
Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1998 Nov;121(1-3):15-22. doi: 10.1016/s0742-8413(98)10027-0.
There are 37 cytochrome P450 families currently identified in animals. The concept of higher order groupings of P450 families called P450 CLANS is introduced. The mammalian CYP3 and CYP5 families belong to the same clan as insect CYP6 and CYP9. All mitochondrial P450s seem to belong to the same clan. Lack of mitochondrial P450s in C. elegans suggests that mitochondrial P450s probably arose from the mistargeting of a microsomal P450 after the coelomates diverged from acoelomates and pseudocoelomates. Different taxonomic groups appear to have recruited different ancestral P450s for expansion as they evolved, since each major taxon seems to have one large cluster of P450s. In insects, this cluster derives from the ancestor to the CYP4 family. Vertebrates and C. elegans may have used the same ancestor independently to generate the CYP1, 2, 17, and 21 families in vertebrates and a large distinctive clan with 45 genes in C. elegans.
目前在动物中已鉴定出37个细胞色素P450家族。引入了称为P450家族的高阶分组概念。哺乳动物的CYP3和CYP5家族与昆虫的CYP6和CYP9家族属于同一家族。所有线粒体P450似乎都属于同一家族。秀丽隐杆线虫中缺乏线粒体P450表明，线粒体P450可能是在真体腔动物与假体腔动物和拟体腔动物分化后，由于微粒体P450的错误靶向而产生的。不同的分类群在进化过程中似乎招募了不同的祖先P450进行扩张，因为每个主要分类单元似乎都有一大群P450。在昆虫中，这个群体源自CYP4家族的祖先。脊椎动物和秀丽隐杆线虫可能独立地利用了同一个祖先，在脊椎动物中产生了CYP1、2、17和21家族，在秀丽隐杆线虫中产生了一个有45个基因的大型独特家族。
