Mira Y, Vayá A, Martínez M, Villa P, Santaolaria M L, Ferrando F, Aznar J
Hemorheology Unit, Clinical Pathology, LA FE Hospital, Valencia, Spain.
Clin Hemorheol Microcirc. 1998 Dec;19(4):265-70.
Deep vein thrombosis (DVT) seems to be related to a hypercoagulation and definite hemorheological alterations, but the importance of these alterations in the development of thrombotic events in the deep vein system has not been established. The present study examines both aspects in a group of 55 patients with DVT; the presence of a hypercoagulable state was assessed by quantifying the prothrombin fragment 1+2 (F1+2) and the thrombin-antithrombin III complex (T-AT), and the main hemorheological parameters were evaluated in the acute state and 6 and 12 months later. The results show marked hemorheological, F1+2, and TAT alterations in the acute phase. After 12 months the pattern shows a modest improvement, but erythrocyte aggregation, fibrinogen, F1+2 and T-AT remain increased with respect to the control group (8.51 +/- 1.43; 331 +/- 81 mg/dl; 1.33 +/- 0.60 nmol/l; 3.54 +/- 1.71 ng/ml vs. 8.10 +/- 1.40; 230 +/- 38; 0.94 +/- 0.40; 1.56 +/- 0.59, respectively). These data suggest that the thrombotic event could be influenced by the previous rheological situation and hypercoagulable state.
深静脉血栓形成（DVT）似乎与高凝状态及明确的血液流变学改变有关，但这些改变在深静脉系统血栓形成事件发展过程中的重要性尚未明确。本研究对55例DVT患者的这两个方面进行了检查；通过定量凝血酶原片段1+2（F1+2）和凝血酶-抗凝血酶III复合物（T-AT）来评估高凝状态的存在情况，并在急性期以及6个月和12个月后评估主要血液流变学参数。结果显示急性期存在明显的血液流变学、F1+2和TAT改变。12个月后，情况有适度改善，但与对照组相比，红细胞聚集、纤维蛋白原、F1+2和T-AT仍升高（分别为8.51±1.43；331±81mg/dl；1.33±0.60nmol/l；3.54±1.71ng/ml，而对照组分别为8.10±1.40；230±38；0.94±0.40；1.56±0.59）。这些数据表明血栓形成事件可能受先前的流变学状况和高凝状态影响。
