Choi S H, Levy M L, McComb J G
Division of Neurosurgery, Childrens Hospital of Los Angeles and Department of Neurological Surgery, University of Southern California, School of Medicine, Los Angeles, Calif., USA.
Pediatr Neurosurg. 1998 Dec;29(6):324-7. doi: 10.1159/000028747.
Current cranioplasty materials include autologous or homologous bone grafts, wire mesh and methyl methacrylate, either alone or in combination. However, each material has its own unique disadvantages. Although hydroxyapatite has been used extensively in other specialties as a bone substitute, the coralline form has rarely been used to repair cranial bone defects. Coralline hydroxyapatite, similar to that found in bone, provides a matrix on which living tissue can form and grow. Because it is an ideal bioimplant, a method of cranioplasty using coralline hydroxyapatite was employed.
The hydroxyapatite granules are mixed with Avitene and autologous blood to form a paste which can be contoured as needed.
Over the past few years, we have used hydroxyapatite either alone or in combination with tantalum mesh in 19 pediatric patients for a variety of conditions. The cosmetic results were good to excellent. Furthermore, postoperative CT scans have documented bony substitution of the hydroxyapatite granules. Follow-up ranged from 1 to 43 months with a mean of 26 months.
In neurosurgical procedures when a bone substitute is needed, hydroxyapatite is an effective alternative to other currently available materials.
目前的颅骨成形材料包括自体或同种异体骨移植、金属丝网和甲基丙烯酸甲酯，单独使用或联合使用。然而，每种材料都有其独特的缺点。尽管羟基磷灰石作为骨替代物已在其他专科广泛应用，但珊瑚状羟基磷灰石很少用于修复颅骨缺损。珊瑚状羟基磷灰石与骨中发现的类似，提供了一个能使活组织形成和生长的基质。由于它是一种理想的生物植入物，采用了一种使用珊瑚状羟基磷灰石的颅骨成形方法。
将羟基磷灰石颗粒与阿维丁和自体血混合形成糊剂，可根据需要塑形。
在过去几年中，我们在19例儿科患者中单独或联合钽网使用羟基磷灰石治疗各种病症。美容效果良好至极佳。此外，术后CT扫描记录了羟基磷灰石颗粒的骨替代情况。随访时间为1至43个月，平均26个月。
在神经外科手术中，当需要骨替代物时，羟基磷灰石是目前其他可用材料的有效替代品。
