Vasankari T, Kujala U, Sarna S, Ahotupa M
Department of Physiology, University of Turku, Finland.
J Sports Med Phys Fitness. 1998 Dec;38(4):281-5.
We studied the effects of supplementation of vitamin C and carbohydrate on acute exercise-induced lipid peroxidation.
two randomized controlled trials.
17 endurance athletes.
in study I, nine athletes repeated twice a 10.5-km maximal run and ingested in a randomized single-blind order either 2.0 g vitamin C or placebo. In study II, eight athletes repeated twice a 27-km maximal run and ingested in randomly either 105 g carbohydrate or placebo. Venous blood samples were taken before the exercise, immediately after the exercise, and after a recovery period of 90 min (study I) or 120 min (study II).
serum diene conjugation, lipid peroxidation.
In study I, there was no difference in serum diene conjugation between the trials during exercise (pre- vs post-exercise). However, during the recovery period (post-exercise vs recovery sample) serum diene conjugation concentration decreased by 11% in the vitamin C trial but not in placebo (p = 0.028). In study II, there was no difference between the carbohydrate and placebo trials.
Vitamin C and carbohydrate do not prevent exercise-induced increase in oxidative stress, but vitamin C, being a potent aqueous antioxidant, seems to decrease the levels of diene conjugation during recovery after exercise. The clinical significance of this phenomenon needs further evaluation.
我们研究了补充维生素C和碳水化合物对急性运动诱导的脂质过氧化的影响。
两项随机对照试验。
17名耐力运动员。
在研究I中，9名运动员以随机单盲顺序重复进行两次10.5公里的最大强度跑步，并摄入2.0克维生素C或安慰剂。在研究II中，8名运动员以随机顺序重复进行两次27公里的最大强度跑步，并摄入105克碳水化合物或安慰剂。在运动前、运动后立即以及90分钟（研究I）或120分钟（研究II）的恢复期后采集静脉血样。
血清二烯共轭、脂质过氧化。
在研究I中，运动期间（运动前与运动后）各试验之间血清二烯共轭无差异。然而，在恢复期（运动后与恢复样本），维生素C试验中血清二烯共轭浓度下降了11%，而安慰剂试验中未下降（p = 0.028）。在研究II中，碳水化合物试验和安慰剂试验之间无差异。
维生素C和碳水化合物不能预防运动诱导的氧化应激增加，但维生素C作为一种有效的水溶性抗氧化剂，似乎能降低运动后恢复期间的二烯共轭水平。这一现象的临床意义需要进一步评估。
