Carlier R Y, Akeson P, Morvan G, Kristoffersen D T, Amar C, Vallée C
Radiology Department, Hôpital Raymond Poincaré, Garches, France.
Acta Radiol. 1999 Jan;40(1):107-10. doi: 10.1080/02841859909174414.
The safety and diagnostic efficacy of iodixanol (Visipaque) 270 mg I/ml was compared to that of iopamidol (Iopamiron) 300 mg I/ml in knee arthrography.
This trial was a bi-center double-blind trial including 128 patients (iodixanol/iopamidol 64/64 patients). Efficacy was evaluated by blinded grading of the diagnostic quality of the p.a. images taken 0, 12 and 25 min after contrast administration by the examining radiologist and later at a consensus evaluation by two experienced skeletal radiologists. Adverse events were recorded.
No patient experienced any adverse event. The proportion of better images at both 12 and 25 min after injection was higher in the iodixanol group compared to the iopamidol group both by the examining radiologist and at the consensus evaluation.
In the knee joint iodixanol is a safe contrast medium. The contrast effect of iodixanol lasted longer than that of iopamidol, which can be important when performing arthrography, especially CT arthrography, where the time between puncture and examination can be prolonged.
在膝关节造影术中，比较碘克沙醇（威视派克）270mgI/ml与碘帕醇（碘必乐）300mgI/ml的安全性和诊断效能。
本试验为双中心双盲试验，纳入128例患者（碘克沙醇/碘帕醇各64例）。造影剂注射后0、12和25分钟时拍摄的前后位图像，由阅片放射科医生进行盲法分级评估诊断质量，随后由两名经验丰富的骨骼放射科医生进行一致性评估。记录不良事件。
无患者发生任何不良事件。在注射后12分钟和25分钟时，碘克沙醇组的优质图像比例高于碘帕醇组，无论是阅片放射科医生的评估还是一致性评估均如此。
在膝关节，碘克沙醇是一种安全的造影剂。碘克沙醇的造影效果持续时间比碘帕醇长，这在进行关节造影时可能很重要，尤其是在CT关节造影中，穿刺与检查之间的时间可能会延长。
