Polito P, Dal Cin P, Kazmierczak B, Rogalla P, Bullerdiek J, Van den Berghe H
Center for Human Genetics, University of Leuven, Belgium.
Cancer Genet Cytogenet. 1999 Jan 15;108(2):107-9. doi: 10.1016/s0165-4608(98)00128-9.
Uterine leiomyomas are characterized by several subgroups with characteristic chromosomal aberrations, mainly 12q14-15, 6p21, or interstitial deletions of chromosomes 3 and 7. For the first two subgroups, aberrations of the HMGIC and HMGIY genes have been described and are held responsible for tumor initiation. For other subgroups no molecular findings have been described as of yet. We focus here on a smaller subgroup of uterine leiomyomas with a ring chromosome 1 either as the only karyotypic deviation or occurring along with other abnormalities. In the p-arm of chromosome 1 HMG17, another member of the high-mobility group of proteins has been localized to the short arm of chromosome 1 (1p35) with two PAC clones on metaphase spreads of a uterine leiomyoma ring(1). Hybridization signals for these probes were not detected within the ring chromosome consistent with loss or deletion of HMG17. These findings suggest that HMG17 does not play a mechanistic role in leiomyoma similar to that observed with other high-mobility proteins.
子宫平滑肌瘤具有几个具有特征性染色体畸变的亚组，主要为12q14 - 15、6p21，或3号和7号染色体的间质缺失。对于前两个亚组，已描述了HMGIC和HMGIY基因的畸变，并认为其与肿瘤发生有关。对于其他亚组，目前尚未有分子学发现的报道。我们在此关注的是子宫平滑肌瘤的一个较小亚组，其具有一条环状1号染色体，要么是唯一的核型异常，要么与其他异常同时出现。在1号染色体的p臂上，高迁移率族蛋白的另一个成员HMG17已定位到1号染色体短臂（1p35），在一个子宫平滑肌瘤环状（1）中期铺片上有两个PAC克隆。在环状染色体内未检测到这些探针的杂交信号，这与HMG17的缺失或删除一致。这些发现表明，HMG17在平滑肌瘤中并不像其他高迁移率蛋白那样发挥机制性作用。
