Dal Cin P, De Smet L, Sciot R, Van Damme B, Van den Berghe H
Center for Human Genetics, University of Leuven, Belgium.
Cancer Genet Cytogenet. 1999 Jan 15;108(2):137-40. doi: 10.1016/s0165-4608(98)00126-5.
Cytogenetic and molecular cytogenetic analysis is reported in a series of 40 tissue samples from 36 patients with Dupuytren's disease, presenting as palmar and/or finger nodules. No consistent structural chromosome changes could be found. Instead, recurrent clonal numerical abnormalities were demonstrated in 22 of 40 tissue nodules, involving trisomies of chromosome 7 or 8 and loss of the Y chromosome. In addition, we showed that trisomy 7 and trisomy 8 were also present in non-dividing cells.
