Juottonen K, Laakso M P, Partanen K, Soininen H
Department of Neuroscience and Neurology, University of Kuopio, Finland.
AJNR Am J Neuroradiol. 1999 Jan;20(1):139-44.
Our purpose was to use volumetric MR imaging to compare the extent of atrophy and discriminative ability of the volumes of two temporal lobe structures, the entorhinal cortex and the hippocampus, between patients with Alzheimer disease and control subjects.
The study group consisted of 30 patients with probable Alzheimer disease diagnosed according to the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA) criteria and 32 healthy control subjects. The MR volumes of the entorhinal cortex and the hippocampus were used for the discriminant function and receiver operator characteristic analysis as well as multivariate analysis of variance for repeated measures to compare their discriminative power.
Compared with control subjects, patients with Alzheimer disease had significantly smaller volumes of the entorhinal cortex and the hippocampus on both sides. Both the receiver operator characteristic and the discriminant function analyses using both volumes classified control subjects and Alzheimer patients with a high degree of accuracy (approximately 90%). Significant group x region interaction favoring hippocampal volumetry was determined by multivariate analysis of variance.
The volumetric measurements of both the entorhinal cortex and hippocampus have comparably high discriminative power in diagnosing Alzheimer disease. In clinical practice, hippocampal volumetry may be more feasible, because the method is easier to use and has less variability.
我们的目的是使用容积磁共振成像（MR成像）来比较阿尔茨海默病患者与对照受试者之间两个颞叶结构，即内嗅皮质和海马体的萎缩程度以及体积的鉴别能力。
研究组由30例根据美国国立神经疾病与中风研究所及阿尔茨海默病及相关疾病协会（NINCDS - ADRDA）标准诊断为可能患有阿尔茨海默病的患者和32名健康对照受试者组成。内嗅皮质和海马体的MR体积用于判别函数和受试者工作特征分析以及重复测量的多变量方差分析，以比较它们的鉴别能力。
与对照受试者相比，阿尔茨海默病患者双侧内嗅皮质和海马体的体积明显较小。使用这两个体积进行的受试者工作特征分析和判别函数分析均以较高的准确率（约90%）对对照受试者和阿尔茨海默病患者进行了分类。通过多变量方差分析确定了有利于海马体容积测量的显著组×区域交互作用。
内嗅皮质和海马体的容积测量在诊断阿尔茨海默病方面具有相当高的鉴别能力。在临床实践中，海马体容积测量可能更可行，因为该方法更易于使用且变异性较小。
