Sergeev S I, Gorodilova V V, Sokolova I I, Repina F F, Babakova S V
Vopr Onkol. 1976;22(7):6-10.
In the present work, the authors have employed a test for blasttransformation and mitotic activity of lymphocytes in the culture with phytohemagglutinin (PHA-Difeo) to estimate the state of cell immunity in patients having malignant melanoma (95). A correlation was made between these tests and the number of lymphoid cells in patients blood prior to and 10--14 days after surgery, radio- and combined therapy. The most informative index of the cell immunity state in patients with malignant melanoma before application of special therapeutic measures was the absolute number of lymphocytes in blood, while following the treatment- the kinetics of the complex of tests under study.
在本研究中，作者采用了一种检测方法，即通过植物血凝素（PHA-Difeo）培养淋巴细胞的 blast 转化和有丝分裂活性，来评估患有恶性黑色素瘤患者的细胞免疫状态（95）。对这些检测结果与手术、放疗和联合治疗前及治疗后 10 - 14 天患者血液中淋巴细胞数量进行了相关性分析。在采取特殊治疗措施前，恶性黑色素瘤患者细胞免疫状态最具信息量的指标是血液中淋巴细胞的绝对数量，而在治疗后，则是所研究检测指标综合的动力学变化。
