替利定在笑气+氧气麻醉期间的呼吸抑制作用。

Respiratory depressant action of tilidine during N2O + O2 anaesthesia.

作者信息

Tammisto T, Tigerstedt I

出版信息

Acta Anaesthesiol Scand. 1976;20(4):378-82. doi: 10.1111/j.1399-6576.1976.tb05053.x.

DOI:10.1111/j.1399-6576.1976.tb05053.x

Abstract

The respiratory depressant actions of pethidine and tilidine during anaesthesia were compared in 18 surgical patients anaesthetized with N2O + O2 after thiopental induction. Five minutes after thiopental, 0.5 mg/kg pethidine or 1.5 mg/kg tilidine were each given intravenously to six patients, the remaining six patients serving as controls. Minute ventilation, respiratory rate, end-tidal CO2 and PCO2 from arterialized venous blood were measured up to 30 min. Pethidine caused the following maximal changes: V -0.98 +/- 0.24 (s.e. mean) 1/min, rate -5.5 +/- 0.7/min, CO2ET + 0.7 +/- 0.1 vol % and PCO2 + 5.7 +/- 1.1 mm Hg. These changes occurred within 10 min of the injection.

摘要

在18例硫喷妥钠诱导后用N2O + O2麻醉的外科手术患者中，比较了哌替啶和替利定在麻醉期间的呼吸抑制作用。硫喷妥钠给药5分钟后，分别给6例患者静脉注射0.5mg/kg哌替啶或1.5mg/kg替利定，其余6例患者作为对照。在长达30分钟的时间内测量分钟通气量、呼吸频率、呼气末二氧化碳和动脉化静脉血的PCO2。哌替啶引起的最大变化如下：分钟通气量-0.98±0.24（标准误均值）升/分钟，呼吸频率-5.5±0.7次/分钟，呼气末二氧化碳+0.7±0.1容积%，PCO2+5.7±1.1毫米汞柱。这些变化在注射后10分钟内出现。