Svendsen U G
Acta Pathol Microbiol Scand A. 1976 Nov;84(6):523-8. doi: 10.1111/j.1699-0463.1976.tb00150.x.
Treatment with desoxycorticosterone acetate (DOCA) and 1 per cent saline as drinking water for 21 days caused a significant and similar increase in blood pressure in haired mice, with a normal thymus function, as in nude mice with genetical aplasia of the thymus. After 57 and 78 days there was, however, a significantly more pronounced increase in blood pressure in haired than in nude mice. A marked degree of round cell infiltration around intrarenal vessels and degenerative changes including wedge-shaped infarcts were observed in the kidneys of the haired mice, commencing after 57 days of treatment, while no such changes were found in nude mice. Thymus grafting in nude mice, successively treated with DOCA and salt, conferred the ability to react with chronic hypertension and intrarenal vascular disease, equal to the reaction seen in haired mice. The present investigation has provided evidence for the existence of an initial thymus independent and a chronic thymus dependent phase of DOCA and salt hypertension in mice. It still remains an unsolved problem whether the secondary blood pressure fall observed in nude athymic mice is a direct consequence of the lack of perivascular cellular immune reactions, or caused by other defects in this strain of mice.
用醋酸去氧皮质酮（DOCA）和1%盐水作为饮用水处理21天，导致具有正常胸腺功能的有毛小鼠的血压显著且类似地升高，与胸腺发生遗传性发育不全的裸鼠情况相同。然而，在57天和78天后，有毛小鼠的血压升高明显比裸鼠更为显著。在处理57天后开始，在有毛小鼠的肾脏中观察到肾内血管周围有明显程度的圆形细胞浸润以及包括楔形梗死在内的退行性变化，而在裸鼠中未发现此类变化。对先用DOCA和盐连续处理的裸鼠进行胸腺移植，使其具有与慢性高血压和肾内血管疾病发生反应的能力，等同于有毛小鼠的反应。本研究为小鼠中DOCA和盐性高血压存在初始的非胸腺依赖性阶段和慢性胸腺依赖性阶段提供了证据。无胸腺裸鼠中观察到的继发性血压下降是血管周围细胞免疫反应缺乏的直接后果，还是由该品系小鼠的其他缺陷引起，这仍然是一个未解决的问题。
