Svendsen U G
Acta Pathol Microbiol Scand A. 1977 Jul;85(4):539-47. doi: 10.1111/j.1699-0463.1977.tb03886.x.
Partial infarction of one kidney and contralateral nephrectomy was followed by a similar initial increase in blood pressure in athymic (nude) and normal mice of the C57/BL/6J strain. The chronic phase of the hypertension was, however, thymus dependent, since the athymic mice failed to maintain an increased blood pressure, in contrast to the normal mice. A response of thymus transplantation in athymic mice was the ability to maintain the blood pressure high in the chronic phase of the hypertension, whereas cyclophosphamide treatment to the normal hypertensive mice decreased the blood pressure in the chronic phase of the hypertension, but not in the early (acute) phase. Some perivascular round cell infiltrations were found in the uninfarcted part of the kidney in normal and thymus-transplanted nude mice after 80 days of hypertension, but the degree of cellular reaction was less than previously observed in the NMRI-strain of mice. Substantial perivascular cellular infiltrations, which appeared to be thymus-dependent, occurred in the ischemic border-zone of the infarcted area. Athymic mice of the NMRI-strain were able to develop the initial blood pressure elevation of DOCA/salt hypertension during the chronic phase of loomis hypertension, in which phase the arterial pressure otherwise would be declining towards normal values.
一侧肾脏部分梗死并对侧肾切除后，C57/BL/6J品系的无胸腺（裸）小鼠和正常小鼠的血压最初均有类似升高。然而，高血压的慢性期依赖于胸腺，因为与正常小鼠相比，无胸腺小鼠无法维持血压升高。无胸腺小鼠的胸腺移植反应是在高血压慢性期能够维持血压处于高位，而对正常高血压小鼠进行环磷酰胺治疗可使高血压慢性期的血压降低，但急性期血压无变化。高血压80天后，在正常和胸腺移植的裸鼠肾脏未梗死部分发现一些血管周围圆形细胞浸润，但细胞反应程度低于先前在NMRI品系小鼠中观察到的情况。梗死区域的缺血边缘区出现大量血管周围细胞浸润，这似乎依赖于胸腺。NMRI品系的无胸腺小鼠在鲁米斯高血压慢性期能够出现去氧皮质酮/盐性高血压的初始血压升高，而在此阶段动脉血压否则会降至正常值。
