Naeser P
Acta Physiol Scand. 1976 Dec;98(4):395-9. doi: 10.1111/j.1748-1716.1976.tb10327.x.
The adrenal function in diabetes mutant mice with misty coat colour (dbm) was investigated by measurements of serum corticosteroids, adrenal weights and adrenal corticosteroid content. Furthermore, the adrenal corticosteroid content was studied in obese-hyperglycemic mice (ob). In the dbm-mice the serum corticosteroid levels were elevated at the age of 5 and 12 months although the adrenal weight only was significantly elevated at the age of 5 months. The adrenal corticosteroid content was significantly lower in the 12 months old dbm-mice. In the ob-mice the adrenal corticosteroid content was elevated at the age of 5 weeks, 5 and 12 months. It is concluded that in both the dbm-mouse and the ob-mouse there is an increased functional activity of the adrenal cortex which may reflect a pituitary hypersection of ACTH, perhaps as a manifestation of a common hypothalamic disorder.
通过测量血清皮质类固醇、肾上腺重量和肾上腺皮质类固醇含量，对毛色模糊的糖尿病突变小鼠（dbm）的肾上腺功能进行了研究。此外，还对肥胖高血糖小鼠（ob）的肾上腺皮质类固醇含量进行了研究。在dbm小鼠中，5个月和12个月大时血清皮质类固醇水平升高，尽管仅5个月大时肾上腺重量显著升高。12个月大的dbm小鼠肾上腺皮质类固醇含量显著降低。在ob小鼠中，5周、5个月和12个月大时肾上腺皮质类固醇含量升高。结论是，dbm小鼠和ob小鼠的肾上腺皮质功能活性均增加，这可能反映了促肾上腺皮质激素（ACTH）的垂体过度分泌，也许是常见下丘脑疾病的一种表现。
