Naeser P
Acta Pathol Microbiol Scand A. 1975 Jan;83(1):120-6. doi: 10.1111/j.1699-0463.1975.tb01363.x.
Quantitative histological methods were used to study the adrenal glands of obese-hyperglycaemic mice and their lean litter mates of various ages. Five weeks old obese mice had significantly enlarged adrenals, due to increased volumes of the zona fasciculata and a persistent cortical X-zone. The enlarged zona fasciculata persisted also in the 5- and 18-month-old obese mice whereas the X-zone had disappeared at these ages. Further, the adrenals of 18-month-old obese mice showed deposits of amyloid in the juxtamedullary cortical zone. It is apparent that the adrenal cortical enlargement coincides in time with the appearance of the other manifestations of the obese-hyperglycaemic syndrome. This further emphasizes that also the adrenal cortical enlargement is an integral part of the syndrome and may contribute to the insulin resistance already at an early stage in the development of the syndrome. The more pronouced weight gain of the adrenal glands of the obese mice together with the morphological changes of the adrenal cortex further suggest an increased ACTH stimulation in these animals. The delayed disappearance of the adrenal X-zone probably reflects the hypogonadism previously demonstrated in these animals.
采用定量组织学方法研究了肥胖高血糖小鼠及其不同年龄的瘦型同窝小鼠的肾上腺。5周龄的肥胖小鼠肾上腺显著增大，这是由于束状带体积增加以及持续存在的皮质X带所致。5月龄和18月龄的肥胖小鼠束状带仍然增大，而X带在这些年龄时已经消失。此外，18月龄肥胖小鼠的肾上腺在近髓质皮质区有淀粉样物质沉积。显然，肾上腺皮质增大与肥胖高血糖综合征的其他表现出现的时间一致。这进一步强调肾上腺皮质增大也是该综合征的一个组成部分，可能在综合征发展的早期阶段就对胰岛素抵抗有影响。肥胖小鼠肾上腺更明显的重量增加以及肾上腺皮质的形态学变化进一步提示这些动物促肾上腺皮质激素（ACTH）刺激增加。肾上腺X带延迟消失可能反映了这些动物先前已证实的性腺功能减退。
