Hahnenberger R W
Acta Physiol Scand. 1976 Dec;98(4):425-32. doi: 10.1111/j.1748-1716.1976.tb10331.x.
The effect of intravitreally injected colchicine (100 mug and 300 mug) and vinblastine (100 mug) on function and sensitivity of the cat iris was studied in vivo. Both antimitotics caused the same effects: The sensitivity to touch of the cornea disappeared after the third day. The normal sensitivity recovered, but after 1 month there was still an anesthetic island in the center of the cornea. The consensual light reflex from the injected to the normal eye declined markedly between 12 and 24 h and was abolished after 4 days. The consensual light reflex from the normal to the injected eye decreased with a similar time course and was completely abolished or strongly reduced after 4-5 days. The function of the sphincter pupillae in the injected eye was reestablished after one month. The affected iris became supersensitive to both pilocarpine and norepinephrine. The degree of supersensitivity in the cholinergic system was closely and inversely related to the degree of impaired function. The function of the dilatator pupillae could not be tested. The observed phenomena were most likely due to inhibition of exoplasmic flow in the nerves supplying the iris and cornea.
在活体状态下研究了玻璃体内注射秋水仙碱（100微克和300微克）和长春碱（100微克）对猫虹膜功能和敏感性的影响。两种抗有丝分裂药物产生了相同的效果：第三天后角膜对触摸的敏感性消失。正常敏感性恢复，但1个月后角膜中央仍有一个麻醉岛。从注射眼到正常眼的同感性光反射在12至24小时之间明显下降，并在4天后消失。从正常眼到注射眼的同感性光反射以类似的时间进程下降，并在4至5天后完全消失或大幅减弱。注射眼瞳孔括约肌的功能在1个月后恢复。受影响的虹膜对毛果芸香碱和去甲肾上腺素均变得超敏感。胆碱能系统中超敏反应的程度与功能受损程度密切相关且呈负相关。瞳孔开大肌的功能无法测试。观察到的现象很可能是由于供应虹膜和角膜的神经中胞质外流受到抑制所致。
