Franzot S P, Salkin I F, Casadevall A
Department of Pharmacology, Cornell University Medical College, New York, New York, USA.
J Clin Microbiol. 1999 Mar;37(3):838-40. doi: 10.1128/JCM.37.3.838-840.1999.
Cryptococcus neoformans var. neoformans presently includes isolates which have been determined by the immunologic reactivity of their capsular polysaccharides to be serotype A and those which have been determined to be serotype D. However, recent analyses of the URA5 sequences and DNA fingerprinting patterns suggest significant genetic differences between the two serotypes. Therefore, we propose to recognize these genotypic distinctions, as well as previously reported phenotypic differences, by restricting C. neoformans var. neoformans to isolates which are serotype D and describing a new variety, C. neoformans var. grubii, for serotype A isolates.
新型隐球菌新型变种目前包括那些根据其荚膜多糖的免疫反应性被确定为血清型A的分离株以及那些被确定为血清型D的分离株。然而，最近对URA5序列和DNA指纹图谱模式的分析表明这两种血清型之间存在显著的基因差异。因此，我们建议通过将新型隐球菌新型变种限定为血清型D的分离株，并为血清型A的分离株描述一个新变种——新型隐球菌格鲁比变种，来认识这些基因型差异以及先前报道的表型差异。
