Ilasi J A, Smilari T F, Kolitz J, Zanzi I, Hajdu S I
Department of Laboratories, North Shore University Hospital, Manhasset, NY 11030, USA.
J Reprod Med. 1999 Jan;44(1):49-52.
Malignant hemangioendothelioma is a neoplasm of vascular origin characterized by irregular vascular channels lined with atypical endothelial cells.
A gravida at 32 weeks' gestation presented with diffuse back and lower leg pain and was diagnosed with multifocal malignant hemangioendothelioma of bone. Computed tomography of the chest also demonstrated a small right atrial density. Three weeks later the patient became septic, and cesarean section was performed. After several cycles of chemotherapy, clinical improvement was noted. However, disease progression was noted thereafter, and the patient died one and a half years after the diagnosis.
Our case was a primary multifocal malignant hemangioendothelioma of bone arising during pregnancy. Considering the absence of pulmonary involvement, it is unlikely that the skeletal lesions represented metastatic deposits from a cardiac primary. With such extensive skeletal disease, the right atrial density probably was a metastatic deposit.
恶性血管内皮瘤是一种起源于血管的肿瘤，其特征为有由非典型内皮细胞衬里的不规则血管通道。
一名孕32周的孕妇出现背部和小腿弥漫性疼痛，被诊断为多灶性骨恶性血管内皮瘤。胸部计算机断层扫描还显示右心房有小密度影。三周后患者发生败血症，随后进行了剖宫产。经过几个周期的化疗，病情有临床改善。然而，此后病情进展，患者在诊断后一年半死亡。
我们的病例是妊娠期间发生的原发性多灶性骨恶性血管内皮瘤。考虑到没有肺部受累，骨骼病变不太可能是心脏原发性肿瘤的转移灶。有如此广泛的骨骼疾病，右心房密度影可能是转移灶。
