Grosz M D, MacNeil M D
USDA-ARS, Fort Keogh Livestock and Range Research Laboratory, Miles City, MT 59301, USA.
J Hered. 1999 Jan-Feb;90(1):233-6. doi: 10.1093/jhered/90.1.233.
The spotted locus is responsible for several phenotypically distinguishable piebald patterns in cattle, including Hereford, or white face (SH), lineback (SP), and recessive spotting (s), in addition to nonspotted (S+). In a backcross mapping population, the S locus has been mapped by genetic linkage to bovine chromosome 6, between microsatellite markers BM4528 and EL03. This region corresponds comparatively to a region on mouse chromosome 5 which houses several coat color mutations, among which homology is possible with Hardy-Zuckerman 4 feline sarcoma viral oncogene homologue (Kit), patch (Ph), and rump white (Rw). Mutations at these loci resemble mutations at the bovine S locus in both phenotype and mode of inheritance. Data are presented which show genetic linkage between the bovine S locus and microsatellite markers on chromosome 6. Candidate genes for the bovine S locus are discussed.
斑点基因座决定了牛的几种表型上可区分的花斑模式，包括赫里福德花斑或白脸（SH）、背线花斑（SP）和隐性斑点（s），此外还有无斑点（S+）。在一个回交作图群体中，通过遗传连锁分析将S基因座定位到牛的6号染色体上，位于微卫星标记BM4528和EL03之间。该区域相对应于小鼠5号染色体上的一个区域，该区域存在几个毛色突变，其中可能与哈代-祖克曼4型猫肉瘤病毒癌基因同源物（Kit）、斑块（Ph）和臀部白色（Rw）存在同源性。这些基因座的突变在表型和遗传方式上都与牛的S基因座突变相似。本文给出的数据表明牛的S基因座与6号染色体上的微卫星标记之间存在遗传连锁。文中还讨论了牛S基因座的候选基因。
