家猫（Felis catus）身上的白色斑点在猫科动物B1染色体上靠近KIT基因的位置。
White spotting in the domestic cat (Felis catus) maps near KIT on feline chromosome B1.
作者信息
Cooper M P, Fretwell N, Bailey S J, Lyons L A
机构信息
Population Health and Reproduction, School of Veterinary Medicine, University of California - Davis, Davis, CA 95616, USA.
出版信息
Anim Genet. 2006 Apr;37(2):163-5. doi: 10.1111/j.1365-2052.2005.01389.x.
Five feline-derived microsatellite markers were genotyped in a large pedigree of cats that segregates for ventral white spotting. Both KIT and EDNRB cause similar white spotting phenotypes in other species. Thus, three of the five microsatellite markers chosen were on feline chromosome B1 in close proximity to KIT; the other two markers were on feline chromosome A1 near EDNRB. Pairwise linkage analysis supported linkage of the white spotting with the three chromosome B1 markers but not with the two chromosome A1 markers. This study indicates that KIT, or another gene within the linked region, is a candidate for white spotting in cats. Platelet-derived growth factor alpha (PDGFRA) is also a strong candidate, assuming that the KIT-PDGFRA linkage group, which is conserved in many mammalian species, is also conserved in the cat.
在一个因腹侧白斑而分离的大型猫科动物谱系中，对五个猫源微卫星标记进行了基因分型。在其他物种中，KIT和EDNRB都会导致类似的白斑表型。因此，所选择的五个微卫星标记中的三个位于猫B1染色体上，与KIT紧密相邻；另外两个标记位于猫A1染色体上，靠近EDNRB。成对连锁分析支持白斑与三个B1染色体标记存在连锁关系，但与两个A1染色体标记不存在连锁关系。这项研究表明，KIT或连锁区域内的另一个基因是猫白斑的候选基因。假设在许多哺乳动物物种中保守的KIT-PDGFRA连锁群在猫中也保守，那么血小板衍生生长因子α（PDGFRA）也是一个有力的候选基因。
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